Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 6/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.49 |
| ▸ | CDK2 | P24941 | 4/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.49 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
| ▸ | PRKCB | P05771 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | PRKCH | P24723 | 1/20 | 0.48 |
| ▸ | PRKCI | P41743 | 1/20 | 0.48 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27116528 | 0.89 | PIK3CG (0.64) | PIK3CGPIK3CAPIK3CBCDK2CDK4 | |
| SCHEMBL27115273 | 0.88 | PIK3CG (0.51) | PIK3CGPIK3CAPIK3CBCDK2JAK2 | |
| SCHEMBL27116135 | 0.85 | GSK3B (0.53) | PIK3CGPIK3CAPIK3CBCDK2JAK2 | |
| SCHEMBL27116600 | 0.84 | ABL1 (0.57) | PIK3CGPIK3CAPIK3CBJAK2EGFR | |
| SCHEMBL27115955 | 0.84 | MKNK1 (0.54) | PIK3CGPIK3CAPIK3CBCDK2JAK2 | |
| SCHEMBL27115952 | 0.82 | PIK3CG (0.50) | PIK3CGPIK3CAPIK3CBCDK2JAK2 | |
| SCHEMBL27115761 | 0.82 | PRKCA (0.51) | PIK3CGPIK3CAPIK3CBCDK2JAK2 | |
| SCHEMBL27115274 | 0.81 | CDK4 (0.50) | PIK3CGPIK3CAPIK3CBCDK2CDK4 | |
| SCHEMBL27115892 | 0.81 | ABL1 (0.59) | PIK3CGPIK3CAPIK3CBEGFRZAP70 | |
| SCHEMBL27115445 | 0.81 | PIK3CG (0.66) | PIK3CGPIK3CAPIK3CBCDK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | claimed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |