Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.50 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | CHUK | O15111 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27115275 | 0.85 | PIK3CG (0.55) | GSK3BPIK3CGPIK3CACDK2PIK3CB | |
| SCHEMBL27116528 | 0.84 | PIK3CG (0.64) | GSK3BPIK3CGPIK3CACDK2PIK3CB | |
| SCHEMBL27116134 | 0.82 | GSK3B (0.52) | GSK3BPIK3CGPIK3CACDK2EIF2AK2 | |
| SCHEMBL27116600 | 0.82 | ABL1 (0.57) | PIK3CGPIK3CAPIK3CBMAPTCDK5 | |
| SCHEMBL27115955 | 0.82 | MKNK1 (0.54) | PIK3CGPIK3CACDK2PIK3CBMAPT | |
| SCHEMBL5733563 | 0.82 | MAPT (0.72) | PIK3CGPIK3CACDK2PIK3CBMAPT | |
| SCHEMBL16941489 | 0.82 | ABL1 (0.61) | GSK3BPIK3CGPIK3CACDK2PIK3CB | |
| SCHEMBL27115445 | 0.81 | PIK3CG (0.66) | PIK3CGPIK3CACDK2PIK3CBMAPT | |
| SCHEMBL27115273 | 0.81 | PIK3CG (0.51) | GSK3BPIK3CGPIK3CACDK2PIK3CB | |
| SCHEMBL27116133 | 0.81 | CDK4 (0.53) | GSK3BPIK3CGPIK3CACDK2PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | claimed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |