Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | CHUK | O15111 | 1/20 | 0.52 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.51 |
| ▸ | PLK1 | P53350 | 5/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16941489 | 0.86 | ABL1 (0.61) | GSK3BCDK2IKBKBCHUKEIF2AK2 | |
| SCHEMBL12800930 | 0.84 | PLK1 (0.51) | GSK3BCDK2IKBKBCHUKEIF2AK2 | |
| SCHEMBL27115274 | 0.83 | CDK4 (0.50) | GSK3BCDK2IKBKBPLK1CLK1 | |
| SCHEMBL27116472 | 0.83 | CDK2 (0.57) | GSK3BCDK2PLK1CLK2DYRK1A | |
| SCHEMBL27116135 | 0.82 | GSK3B (0.53) | GSK3BCDK2IKBKBCHUKEIF2AK2 | |
| SCHEMBL27115894 | 0.80 | CAMK2D (0.60) | PLK1CLK1CLK2DYRK1ACLK4 | |
| SCHEMBL27116599 | 0.80 | ABL1 (0.62) | GSK3BCDK2IKBKBPLK1CAMK2D | |
| SCHEMBL5733933 | 0.80 | CAMK2D (0.71) | CDK2EIF2AK2PLK1CAMK2DABL1 | |
| SCHEMBL27154547 | 0.79 | SYK (0.50) | PLK1CLK1CLK2DYRK1ACLK4 | |
| SCHEMBL27115272 | 0.79 | PLK1 (0.47) | CDK2PLK1CLK1CLK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | claimed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |