Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 7/20 | 0.43 |
| ▸ | BCR | P11274 | 7/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.42 |
| ▸ | PLK1 | P53350 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | PRKCA | P17252 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27116019 | 0.81 | CLK1 (0.59) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL27138987 | 0.79 | KMO (0.47) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL27116471 | 0.78 | CLK1 (0.66) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL27115596 | 0.75 | SYK (0.65) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL4737084 | 0.73 | SYK (0.62) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL9014180 | 0.72 | ABL1 (0.68) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL27144345 | 0.71 | SYK (0.49) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL27116018 | 0.71 | ABL1 (0.55) | ABL1BCRPLK1CDK2SRC | |
| SCHEMBL3514414 | 0.70 | AURKA (0.64) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL15533886 | 0.70 | CLK1 (0.67) | CLK1CLK2DYRK1ACLK4DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |