Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4435307 | 0.79 | LMNA (0.48) | LMNAALDH1A1KMT2AHSD17B10MAPT | |
| SCHEMBL473405 | 0.79 | ALDH1A1 (0.40) | LMNAALDH1A1KMT2AMAPTTDP1 | |
| SCHEMBL28272326 | 0.76 | LMNA (0.50) | LMNAALDH1A1KMT2AHSD17B10MAPT | |
| SCHEMBL6870490 | 0.76 | LMNA (0.45) | LMNAALDH1A1KMT2AHSD17B10MAPT | |
| SCHEMBL27934059 | 0.76 | LMNA (0.45) | LMNAALDH1A1KMT2AHSD17B10MAPT | |
| SCHEMBL487497 | 0.76 | MAPT (0.46) | LMNAALDH1A1KMT2AHSD17B10MAPT | |
| SCHEMBL27682606 | 0.76 | LMNA (0.45) | LMNAALDH1A1KMT2AHSD17B10MAPT | |
| Hydrochloric Acid SCHEMBL5339516 | 0.74 | LMNA (0.48) | LMNAALDH1A1KMT2AHSD17B10MAPT | |
| SCHEMBL11120096 | 0.72 | LMNA (0.41) | LMNAALDH1A1KMT2AHSD17B10MAPT | |
| SCHEMBL23716956 | 0.72 | ALDH1A1 (0.50) | LMNAALDH1A1KMT2AHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104837829-B | Inhibitor compound | 癌症研究科技有限公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-103570630-B | Nitrogen heterocyclic derivative and the application in medicine thereof | SUNSHINE LAKE PHARMA CO.,LTD. (CN) | 2016-04-20 | — | — | CN | disclosed |
| CN-104837829-A | Inhibitor compounds | CANCER REC TECH LTD | 2015-08-12 | — | — | CN | disclosed |
| CN-103570630-A | Heterocyclic nitrogen derivative and application thereof in medicines | GUANGDONG HEC PHARMACEUTICAL | 2014-02-12 | — | — | CN | disclosed |
| CN-103492389-A | Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors | ORIGENIS GMBH | 2014-01-01 | — | — | CN | disclosed |
| EP-2445886-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151791-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |