Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6870490 | 0.83 | LMNA (0.45) | LMNAALDH1A1KMT2AHSD17B10MAPT | |
| SCHEMBL2712919 | 0.79 | LMNA (0.45) | LMNAALDH1A1KMT2AHSD17B10MAPT | |
| SCHEMBL27934059 | 0.79 | LMNA (0.45) | LMNAALDH1A1KMT2AHSD17B10MAPT | |
| SCHEMBL27682606 | 0.79 | LMNA (0.45) | LMNAALDH1A1KMT2AHSD17B10MAPT | |
| SCHEMBL487497 | 0.79 | MAPT (0.46) | LMNAALDH1A1KMT2AHSD17B10MAPT | |
| SCHEMBL28272326 | 0.79 | LMNA (0.50) | LMNAALDH1A1KMT2AHSD17B10MAPT | |
| Hydrochloric Acid SCHEMBL5339516 | 0.78 | LMNA (0.48) | LMNAALDH1A1KMT2AHSD17B10MAPT | |
| SCHEMBL11120096 | 0.75 | LMNA (0.41) | LMNAALDH1A1KMT2AHSD17B10MAPT | |
| SCHEMBL23716956 | 0.75 | ALDH1A1 (0.50) | LMNAALDH1A1KMT2AHSD17B10MAPT | |
| SCHEMBL6870782 | 0.75 | LMNA (0.41) | LMNAALDH1A1KMT2AHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132184-A1 | NOVEL PYRIMIDINE DERIVATIVES 698 | AstraZeneca AB (SE) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008104754-A1 | NOVEL PYRIMIDINE DERIVATIVES 698 | ASTRAZENECA AB (SE) | 2008-09-04 | — | — | WO | disclosed |