Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | APAF1 | O14727 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 2/20 | 0.35 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2712897 | 0.84 | ADORA2A (0.36) | KDM4ESMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL2712937 | 0.84 | PIK3CA (0.41) | KDM4ESMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL2712232 | 0.83 | ADORA2A (0.39) | KDM4ESMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL23304303 | 0.81 | HTR2A (0.40) | KDM4ESMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL30260181 | 0.81 | HTR2A (0.40) | KDM4ESMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL6465278 | 0.79 | MAP4K1 (0.37) | PIK3CAPIK3CBRBP4 | |
| SCHEMBL2712865 | 0.76 | HDAC1 (0.34) | RBP4ALDH1A1GPR119 | |
| SCHEMBL2711532 | 0.75 | ALDH1A1 (0.60) | KDM4EMAPTGAAALDH1A1KMT2A | |
| SCHEMBL2178736 | 0.74 | LMNA (0.40) | KDM4ESMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL3716189 | 0.74 | LMNA (0.46) | KDM4ESMN1; SMN2NPC1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |