Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.32 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 2/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14976012 | 0.85 | CA14 (0.37) | HDAC6HDAC1HDAC2CA14CTSK | |
| SCHEMBL8616170 | 0.82 | NOS2 (0.46) | MEN1GAAKMT2ANOS1NOS3 | |
| SCHEMBL854273 | 0.82 | HDAC6 (0.35) | HDAC6HDAC1HDAC2CA14CTSK | |
| SCHEMBL14651989 | 0.81 | CTSK (0.42) | HDAC6HDAC1HDAC2CA14CTSK | |
| SCHEMBL8310669 | 0.80 | CA14 (0.41) | HDAC6HDAC1HDAC2CA14CA1 | |
| SCHEMBL6024664 | 0.80 | CA1 (0.38) | HDAC6HDAC1HDAC2CA14CTSK | |
| SCHEMBL1884648 | 0.79 | CA14 (0.40) | HDAC6HDAC1HDAC2CA14CTSK | |
| SCHEMBL27942277 | 0.79 | HDAC6 (0.37) | HDAC6HDAC1HDAC2CA14CA1 | |
| SCHEMBL27885574 | 0.78 | CTSK (0.32) | HDAC6HDAC1HDAC2CA14CTSK | |
| SCHEMBL22199322 | 0.78 | CA14 (0.43) | HDAC6HDAC1HDAC2CA14CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10112928-B2 | Inhibitors of SYK | HOFFMANN-LA ROCHE INC. (US) | 2018-10-30 | — | — | US | disclosed |
| US-9902688-B2 | Benzamides and nicotinamides as Syk modulators | PORTOLA PHARMACEUTICALS, INC. (US) | 2018-02-27 | — | — | US | disclosed |
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |
| US-20160318852-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | ALEXION PHARMACEUTICALS, INC. | 2016-11-03 | — | — | US | disclosed |
| CN-105683196-A | Aryl ether based kinase inhibitors | 百时美施贵宝公司 | 2016-06-15 | — | — | CN | disclosed |
| US-9359375-B2 | Benzamides and nicotinamides as Syk modulators | PORTOLA PHARMACEUTICALS, INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-20150284367-A1 | INHIBITORS OF SYK | HOFFMANN-LA ROCHE INC. | 2015-10-08 | — | — | US | disclosed |
| EP-2909174-A1 | INHIBITORS OF SYK | F. Hoffmann-La Roche AG (CH) | 2015-08-26 | — | — | EP | disclosed |
| US-20150038492-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | ALEXION PHARMACEUTICALS, INC. | 2015-02-05 | — | — | US | disclosed |
| US-8846928-B2 | Benzamides and nicotinamides as Syk modulators | PORTOLA PHARMACEUTICALS, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| WO-2014060371-A1 | INHIBITORS OF SYK | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-24 | — | — | WO | disclosed |
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| US-20120142671-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-06-07 | — | — | US | disclosed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| CN-1976706-B | FGFR3 inhibition and treatment of multiple myeloma | NOVARTIS VACCINES & DIAGNOSTIC | 2012-01-18 | — | — | CN | disclosed |
| CN-1976706-A | FGFR3 inhibition and treatment of multiple myeloma | CHIRON CORP (US) | 2007-06-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142671-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | SYK, BTK, NADK | HDAC6 138/4885HDAC1 215/4885HDAC2 148/4885 |
| US-20150284367-A1 | INHIBITORS OF SYK | SYK, BTK, LYN | HDAC6 1050/4885HDAC1 1765/4885HDAC2 1704/4885 |
| US-20160318852-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | SYK, BTK, NADK | HDAC6 138/4885HDAC1 215/4885HDAC2 148/4885 |
| US-10112928-B2 | Inhibitors of SYK | SYK, BTK, LYN | HDAC6 1050/4885HDAC1 1765/4885HDAC2 1704/4885 |
| US-20150038492-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | SYK, BTK, NADK | HDAC6 138/4885HDAC1 215/4885HDAC2 148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.