Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 7/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27154484 | 0.89 | DRD2 (0.43) | HDAC6DRD2POLBKDM4EMAPT | |
| SCHEMBL27141041 | 0.87 | DRD2 (0.40) | HDAC6DRD2POLBKDM4EMAPT | |
| SCHEMBL27148495 | 0.83 | DRD2 (0.41) | HDAC6DRD2POLBGAAKDM4E | |
| SCHEMBL27148891 | 0.82 | DRD2 (0.46) | HDAC6DRD2KDM4EMAPK1HPGD | |
| SCHEMBL27141155 | 0.81 | PRSS1 (0.45) | HDAC6ADORA1POLBGAAKDM4E | |
| SCHEMBL30782338 | 0.80 | TNF (0.46) | DRD2POLBKDM4EMAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL27149028 | 0.80 | PRSS1 (0.44) | HDAC6ADORA1POLBGAAKDM4E | |
| SCHEMBL31607750 | 0.79 | DRD2 (0.41) | DRD2POLBDRD3SIGMAR1MEN1 | |
| SCHEMBL980137 | 0.78 | ADORA1 (0.60) | HDAC6ADORA1GAAKDM4EMAPT | |
| SCHEMBL12922700 | 0.77 | KDM4E (0.48) | HDAC6POLBGAAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4577537-A1 | SUBSTITUTED BICYCLES AS HSET INHIBITORS | Merck Patent GmbH (DE) | 2025-07-02 | — | — | EP | disclosed |
| CN-120091998-A | Substituted bicyclic rings as HSET inhibitors | 默克专利股份公司 | 2025-06-03 | — | — | CN | disclosed |
| WO-2024042007-A1 | SUBSTITUTED BICYCLES AS HSET INHIBITORS | MERCK PATENT GMBH (DE) | 2024-02-29 | — | — | WO | disclosed |