Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 12/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27145574 | 0.84 | BACE1 (0.33) | ALOX5BACE1LOXL2 | |
| SCHEMBL27139250 | 0.82 | ALOX5 (0.41) | ALOX5BACE1LOXL2OPRM1 | |
| SCHEMBL27144945 | 0.82 | BACE1 (0.34) | BACE1LOXL2 | |
| SCHEMBL27153212 | 0.81 | BACE1 (0.33) | BACE1LOXL2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL27141779 | 0.81 | BACE1 (0.33) | BACE1LOXL2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL26876154 | 0.80 | ALOX5 (0.46) | ALOX5PTGS1PTGS2 | |
| SCHEMBL27142259 | 0.75 | LOXL2 (0.37) | BACE1LOXL2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL27907651 | 0.74 | OPRM1 (0.38) | ALOX5KDM4EHTTHSD17B10OPRM1 | |
| SCHEMBL30848052 | 0.74 | LOXL2 (0.40) | BACE1LOXL2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL16198445 | 0.74 | LOXL2 (0.40) | BACE1LOXL2TAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044730-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |