Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 12/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27150592 | 1.00 | HSD11B1 (0.57) | HSD11B1ROCK2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL24581583 | 0.81 | HSD11B1 (0.54) | HSD11B1TP53MAPTHPGD | |
| SCHEMBL24581805 | 0.81 | HSD11B1 (0.54) | HSD11B1TP53MAPTHPGD | |
| SCHEMBL24581588 | 0.81 | HSD11B1 (0.54) | HSD11B1TP53MAPTHPGD | |
| SCHEMBL21194810 | 0.78 | HSD11B1 (0.42) | HSD11B1ROCK2 | |
| SCHEMBL27074366 | 0.78 | HSD11B1 (0.42) | HSD11B1ROCK2 | |
| SCHEMBL22533300 | 0.76 | HSD11B1 (0.53) | HSD11B1ROCK2 | |
| Hydrochloric Acid SCHEMBL22532901 | 0.75 | HSD11B1 (0.53) | HSD11B1ROCK2 | |
| SCHEMBL16118170 | 0.74 | KDM4E (0.54) | HSD11B1MAPTHPGD | |
| SCHEMBL9986181 | 0.74 | HPGDS (0.50) | HSD11B1ROCK2ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240067631-A1 | PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS | CYTOKINETICS, INC. | 2024-02-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240067631-A1 | PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS | NAMPT, NNT, NAPRT | HSD11B1 1178/4885ROCK2 1779/4885RAB9A 760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.