Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24581588 | 0.94 | HSD11B1 (0.54) | HPGDSHSD11B1MAPTJAK1GPR119 | |
| SCHEMBL24581583 | 0.94 | HSD11B1 (0.54) | HPGDSHSD11B1MAPTJAK1GPR119 | |
| SCHEMBL24581805 | 0.94 | HSD11B1 (0.54) | HPGDSHSD11B1MAPTJAK1GPR119 | |
| SCHEMBL26126218 | 0.88 | PIK3CA (0.46) | HPGDSHSD11B1MAPTJAK1GPR119 | |
| SCHEMBL16118170 | 0.86 | KDM4E (0.54) | HPGDSHSD11B1MAPTMEN1KMT2A | |
| SCHEMBL21424901 | 0.80 | PROKR1 (0.49) | HPGDSMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL25343613 | 0.80 | PDE4B (0.52) | HPGDSHSD11B1MAPTMEN1ALDH1A1 | |
| SCHEMBL26667052 | 0.80 | PDE4B (0.52) | HPGDSHSD11B1MAPTMEN1ALDH1A1 | |
| SCHEMBL6359096 | 0.79 | ALDH1A1 (0.56) | HPGDSMAPTALDH1A1GPR119PRMT5 | |
| SCHEMBL26667019 | 0.79 | HPGDS (0.49) | HPGDSMAPTMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8080566-B1 | Carbazole inhibitors of histamine receptors for the treatment of disease | KALYPSYS, INC (US) | 2011-12-20 | — | — | US | disclosed |
| US-8080566-B1 | Carbazole inhibitors of histamine receptors for the treatment of disease | KALYPSYS, INC (US) | 2011-12-20 | — | — | US | disclosed |
| US-8080566-B1 | Carbazole inhibitors of histamine receptors for the treatment of disease | KALYPSYS, INC (US) | 2011-12-20 | — | — | US | disclosed |