SCHEMBL27154530

SCHEMBL27154530

O=S(=O)(NC(CNc1ccccc1)C1CCC1)c1cc(Br)c(Cl)cc1F

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 2/20 0.37
PGR P06401 1/20 0.37
NR3C2 P08235 1/20 0.37
HRH4 Q9H3N8 1/20 0.33
SCN5A Q14524 4/20 0.33
SCN1A P35498 3/20 0.33
SCN8A Q9UQD0 3/20 0.33
CYP3A4 P08684 2/20 0.33
SCN9A Q15858 2/20 0.33
SOS1 Q07889 2/20 0.33
TP53 P04637 2/20 0.32
MAPT P10636 2/20 0.32
PPARG P37231 1/20 0.32
LMNA P02545 1/20 0.32
BDKRB1 P46663 1/20 0.32
TAAR1 Q96RJ0 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30807690 1.00 NR3C1 (0.37) NR3C1PGRNR3C2HRH4SCN5A
SCHEMBL27154529 1.00 NR3C1 (0.37) NR3C1PGRNR3C2HRH4SCN5A
SCHEMBL31092623 0.96 NR3C1 (0.38) NR3C1PGRNR3C2HRH4SCN5A
SCHEMBL27146021 0.96 NR3C1 (0.38) NR3C1PGRNR3C2HRH4SCN5A
SCHEMBL30807621 0.96 NR3C1 (0.38) NR3C1PGRNR3C2HRH4SCN5A
SCHEMBL27146019 0.96 NR3C1 (0.38) NR3C1PGRNR3C2HRH4SCN5A
SCHEMBL31092589 0.91 NR3C1 (0.40) NR3C1PGRNR3C2SCN5ASCN1A
SCHEMBL30807603 0.88 NR3C1 (0.39) NR3C1PGRNR3C2SCN5ASCN1A
SCHEMBL27145036 0.88 NR3C1 (0.39) NR3C1PGRNR3C2SCN5ASCN1A
SCHEMBL27145035 0.88 NR3C1 (0.39) NR3C1PGRNR3C2SCN5ASCN1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240368096-A1 Fused Heterobicyclic Antiviral Agents ENANTA PHARMACEUTICALS, INC. 2024-11-07 US disclosed
US-20240140922-A1 FUSED HETEROBICYCLIC ANTIVIRAL AGENTS ENANTA PHARMACEUTICALS, INC. 2024-05-02 US disclosed
WO-2024044183-A1 FUSED HETEROBICYCLIC ANTIVIRAL AGENTS ENANTA PHARMACEUTICALS, INC. (US) 2024-02-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240368096-A1 Fused Heterobicyclic Antiviral Agents HAVCR2, HDGF, SLC10A1 NR3C1 2938/4885PGR 2060/4885NR3C2 3200/4885
US-20240140922-A1 FUSED HETEROBICYCLIC ANTIVIRAL AGENTS HAVCR2, HDGF, SLC10A1 NR3C1 2654/4885PGR 1907/4885NR3C2 2862/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.