Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.43 |
| ▸ | FADS1 | O60427 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21772619 | 0.86 | TRPA1 (0.49) | PIK3CDTRPA1FADS1USP2LMNA | |
| SCHEMBL21772620 | 0.77 | PIK3CD (0.46) | PIK3CDTRPA1FADS1USP2CYP1A2 | |
| SCHEMBL2714343 | 0.77 | PIK3CD (0.53) | PIK3CDTRPA1 | |
| SCHEMBL890508 | 0.77 | PIK3CD (0.58) | PIK3CDTRPA1FADS1 | |
| SCHEMBL17397271 | 0.76 | TAAR1 (0.42) | PIK3CDTRPA1TAAR1 | |
| SCHEMBL21772472 | 0.76 | TRPA1 (0.42) | PIK3CDTRPA1FADS1 | |
| SCHEMBL21772732 | 0.76 | SLC2A1 (0.42) | PIK3CDTRPA1FADS1CYP1A2CYP2C9 | |
| SCHEMBL21772442 | 0.74 | PIK3CD (0.58) | PIK3CDTRPA1FADS1CYP3A4CYP2C9 | |
| SCHEMBL2549015 | 0.74 | AKT1 (0.48) | PIK3CDTRPA1SLC2A1 | |
| SCHEMBL21772584 | 0.73 | PIK3CD (0.63) | PIK3CDTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445898-A2 | 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES AS PI3K INHIBITORS | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151735-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |