Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | MDM4 | O15151 | 1/20 | 0.30 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29819745 | 1.00 | IL1B (0.33) | IL1BP2RX7LRRK2AURKACDK1 | |
| SCHEMBL27156706 | 1.00 | IL1B (0.33) | IL1BP2RX7LRRK2AURKACDK1 | |
| SCHEMBL27156880 | 0.93 | AURKA (0.37) | AURKACDK1AURKBMDM4MDM2 | |
| SCHEMBL27156527 | 0.93 | AURKA (0.37) | AURKACDK1AURKBMDM4MDM2 | |
| SCHEMBL27156392 | 0.92 | AURKA (0.36) | AURKACDK1AURKBMDM4MDM2 | |
| SCHEMBL29819718 | 0.92 | AURKA (0.36) | AURKACDK1AURKBMDM4MDM2 | |
| SCHEMBL27156644 | 0.92 | AURKA (0.36) | AURKACDK1AURKBMDM4MDM2 | |
| SCHEMBL27156388 | 0.92 | AURKA (0.36) | AURKACDK1AURKBMDM4MDM2 | |
| SCHEMBL29819920 | 0.92 | AURKA (0.36) | AURKACDK1AURKBMDM4MDM2 | |
| SCHEMBL27156740 | 0.89 | KMO (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11918582-B2 | Pyrazole pyrimidine compounds and uses thereof | RAPT THERAPEUTICS, INC. (US) | 2024-03-05 | — | — | US | disclosed |
| US-20220305018-A1 | PYRAZOLE PYRIMIDINE COMPOUNDS AND USES THEREOF | RAPT THERAPEUTICS, INC. | 2022-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11918582-B2 | Pyrazole pyrimidine compounds and uses thereof | DCK, MCL1, DTYMK | IL1B 3067/4885P2RX7 1357/4885LRRK2 2451/4885 |
| US-20220305018-A1 | PYRAZOLE PYRIMIDINE COMPOUNDS AND USES THEREOF | DCK, MCL1, DTYMK | IL1B 3067/4885P2RX7 1357/4885LRRK2 2451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.