Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914826 | 1.00 | HTR1D (0.31) | HTR1DHTR2CP2RX7 | |
| SCHEMBL27159789 | 0.81 | LPL (0.31) | — | |
| SCHEMBL29914852 | 0.81 | LPL (0.31) | — | |
| SCHEMBL15634931 | 0.78 | LPL (0.36) | P2RX7 | |
| SCHEMBL30748977 | 0.78 | LPL (0.36) | P2RX7 | |
| SCHEMBL14746201 | 0.78 | NOTUM (0.40) | P2RX7 | |
| SCHEMBL31317613 | 0.76 | F11 (0.34) | P2RX7 | |
| SCHEMBL26625796 | 0.76 | F11 (0.34) | P2RX7 | |
| SCHEMBL25425144 | 0.75 | KDM4E (0.36) | — | |
| SCHEMBL30716028 | 0.75 | KDM4E (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4330246-A1 | HALO-SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | Ontario Institute for Cancer Research (OICR) (CA) | 2024-03-06 | — | — | EP | disclosed |
| CN-117597336-A | Halogen substituted amino aza-heteroaryl compounds as inhibitors of hematopoietic progenitor kinase 1 (HPK 1) | 安大略省癌症研究所(OICR) | 2024-02-23 | — | — | CN | disclosed |