Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2716212 | 0.89 | CNR2 (0.39) | CNR2TRPV1TRPA1KCNH2TRPM8 | |
| SCHEMBL2719291 | 0.89 | CNR2 (0.41) | CNR2PDGFRBPDGFRATRPV1TRPA1 | |
| SCHEMBL4562325 | 0.81 | TRPV1 (0.40) | PDGFRBPDGFRATRPV1TRPA1KCNH2 | |
| SCHEMBL2384227 | 0.80 | PI4KB (0.50) | PDGFRBTRPV1FAAHHCAR2PI4KB | |
| SCHEMBL2385334 | 0.80 | PDGFRB (0.42) | PDGFRBPDGFRAKCNH2PI4KB | |
| SCHEMBL2384683 | 0.79 | PDGFRB (0.45) | PDGFRBTRPV1LMNA | |
| SCHEMBL2385038 | 0.79 | TRPV1 (0.48) | TRPV1HSD17B10 | |
| SCHEMBL2720162 | 0.79 | NPSR1 (0.37) | TRPV1HSD17B10 | |
| SCHEMBL2718774 | 0.78 | CNR2 (0.43) | CNR2TRPV1TRPA1KCNH2TRPM8 | |
| SCHEMBL2384210 | 0.78 | PI4KB (0.43) | PDGFRBPI4KBLMNALIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | claimed |
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |