Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2713978 | 0.89 | SYK (0.54) | SYK | |
| SCHEMBL2712474 | 0.85 | SYK (0.54) | SYK | |
| SCHEMBL2696712 | 0.84 | SYK (0.58) | SYK | |
| SCHEMBL2694989 | 0.82 | SYK (0.60) | SYK | |
| SCHEMBL2696639 | 0.81 | SYK (0.59) | SYK | |
| SCHEMBL2716322 | 0.81 | SYK (0.47) | SYK | |
| SCHEMBL2712299 | 0.80 | SYK (0.55) | SYK | |
| SCHEMBL2696460 | 0.78 | STAT6 (0.57) | SYK | |
| SCHEMBL2714357 | 0.78 | SYK (0.54) | SYK | |
| SCHEMBL2713612 | 0.78 | MAPK10 (0.55) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |