Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 6/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.55 |
| ▸ | SYK | P43405 | 4/20 | 0.51 |
| ▸ | STAT6 | P42226 | 10/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2714011 | 0.92 | SYK (0.51) | MAPK10MAPK9SYKSTAT6 | |
| SCHEMBL2714357 | 0.89 | SYK (0.54) | MAPK10MAPK9SYKSTAT6 | |
| SCHEMBL2713978 | 0.89 | SYK (0.54) | SYK | |
| SCHEMBL2715553 | 0.88 | SYK (0.49) | MAPK10MAPK9SYKSTAT6 | |
| SCHEMBL2712299 | 0.86 | SYK (0.55) | MAPK10MAPK9SYKMAPK8 | |
| SCHEMBL2713052 | 0.85 | MAPT (0.48) | — | |
| SCHEMBL2713291 | 0.83 | JAK3 (0.45) | SYK | |
| SCHEMBL2712360 | 0.81 | SYK (0.45) | MAPK10SYKSTAT6MAPK8 | |
| SCHEMBL2713091 | 0.80 | EGFR (0.44) | SYK | |
| SCHEMBL2716322 | 0.80 | SYK (0.47) | MAPK10SYKMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |