Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 5/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2713612 | 0.89 | MAPK10 (0.55) | SYKMAPK9MAPK10STAT6 | |
| SCHEMBL2713978 | 0.87 | SYK (0.54) | SYK | |
| SCHEMBL2712299 | 0.85 | SYK (0.55) | SYKMAPK9MAPK10JAK3JAK2 | |
| SCHEMBL2714011 | 0.82 | SYK (0.51) | SYKMAPK9MAPK10STAT6JAK2 | |
| SCHEMBL2714883 | 0.82 | SYK (0.47) | SYKMAPK9MAPK10BTKSTAT6 | |
| SCHEMBL2712360 | 0.80 | SYK (0.45) | SYKMAPK10STAT6JAK3IRAK4 | |
| SCHEMBL2715553 | 0.79 | SYK (0.49) | SYKMAPK9MAPK10STAT6JAK3 | |
| SCHEMBL2716322 | 0.79 | SYK (0.47) | SYKMAPK10JAK3 | |
| SCHEMBL2716479 | 0.78 | SYK (0.53) | SYK | |
| SCHEMBL2713076 | 0.77 | JAK3 (0.43) | JAK3IRAK4JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |