Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.55 |
| ▸ | JAK3 | P52333 | 4/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | STK4 | Q13043 | 2/20 | 0.43 |
| ▸ | STK3 | Q13188 | 2/20 | 0.43 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.43 |
| ▸ | RPS6KA6 | Q9UK32 | 2/20 | 0.43 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2713978 | 0.91 | SYK (0.54) | SYK | |
| SCHEMBL2712825 | 0.89 | JAK3 (0.59) | SYKJAK3JAK1JAK2TYK2 | |
| SCHEMBL2712474 | 0.87 | SYK (0.54) | SYKJAK3JAK1JAK2CHEK1 | |
| SCHEMBL2713612 | 0.86 | MAPK10 (0.55) | SYKMAPK10MAPK8MAPK9 | |
| SCHEMBL2714357 | 0.85 | SYK (0.54) | SYKJAK3JAK1JAK2TYK2 | |
| SCHEMBL2716322 | 0.83 | SYK (0.47) | SYKJAK3MAPK10MAPK8 | |
| SCHEMBL12301627 | 0.81 | JAK3 (0.66) | SYKJAK3JAK1JAK2MAPT | |
| SCHEMBL2713052 | 0.81 | MAPT (0.48) | MAPT | |
| SCHEMBL2716479 | 0.80 | SYK (0.53) | SYK | |
| SCHEMBL2714011 | 0.79 | SYK (0.51) | SYKJAK1JAK2MAPK10MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |