Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717862 | 0.93 | NPSR1 (0.46) | NPSR1HSD17B10MAPTTRPV1TRPA1 | |
| SCHEMBL2716871 | 0.93 | NPSR1 (0.47) | NPSR1HSD17B10MAPTTRPV1TRPA1 | |
| SCHEMBL2716429 | 0.90 | NPSR1 (0.53) | NPSR1HSD17B10TRPV1CA12CA1 | |
| SCHEMBL2384960 | 0.88 | MAPT (0.45) | NPSR1HSD17B10MAPTTRPV1 | |
| SCHEMBL2720307 | 0.87 | TRPV1 (0.42) | NPSR1HSD17B10MAPTTRPV1TRPA1 | |
| SCHEMBL2383256 | 0.84 | TRPV1 (0.49) | TRPV1CA12CA1CA2CA9 | |
| SCHEMBL2717524 | 0.84 | TRPV1 (0.42) | NPSR1HSD17B10MAPTTRPV1TRPA1 | |
| SCHEMBL2717889 | 0.83 | TRPV1 (0.45) | NPSR1HSD17B10TRPV1TRPA1KCNH2 | |
| SCHEMBL2383066 | 0.83 | TRPV1 (0.52) | NPSR1HSD17B10MAPTTRPV1 | |
| SCHEMBL2719037 | 0.83 | RBP4 (0.44) | NPSR1HSD17B10TRPV1TRPA1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | claimed |
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |