Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | GRM5 | P41594 | 5/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30055761 | 1.00 | PIK3CA (0.42) | PIK3CAMTORGRM5NUDT1KCNH2 | |
| SCHEMBL30055557 | 0.79 | FADS1 (0.49) | PIK3CAMTORGRM5KCNH2HPGD | |
| SCHEMBL12269780 | 0.79 | PIK3CA (0.60) | PIK3CAMTORGRM5MAPT | |
| SCHEMBL12269859 | 0.73 | GRM5 (0.41) | PIK3CAMTORGRM5KCNH2CYP1A2 | |
| SCHEMBL31614582 | 0.72 | ABL1 (0.46) | GRM5KCNH2GRM4ABL1MEN1 | |
| SCHEMBL30130235 | 0.72 | PARP1 (0.35) | PIK3CAMTORGRM4 | |
| SCHEMBL30707869 | 0.70 | KCNH2 (0.67) | GRM5KCNH2CYP2C9PTGDR2HAO1 | |
| SCHEMBL4562631 | 0.70 | KCNH2 (0.67) | GRM5KCNH2CYP2C9PTGDR2HAO1 | |
| SCHEMBL1477031 | 0.70 | GRM5 (0.50) | GRM5KCNH2CYP2C9PTGDR2CYP1A2 | |
| SCHEMBL30669242 | 0.70 | GRM5 (0.50) | GRM5KCNH2CYP2C9PTGDR2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4333819-A1 | TREATMENT OF PHARMACORESISTANT EPILEPSY | Katholieke Universiteit Leuven (BE) | 2024-03-13 | — | — | EP | claimed |
| EP-4333819-A1 | TREATMENT OF PHARMACORESISTANT EPILEPSY | Katholieke Universiteit Leuven (BE) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022233877-A1 | TREATMENT OF PHARMACORESISTANT EPILEPSY | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2022-11-10 | — | — | WO | disclosed |