Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 3/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6128776 | 0.93 | ALDH1A1 (0.41) | GNRHRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2718042 | 0.90 | PIK3CD (0.40) | GNRHRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2717296 | 0.90 | GNRHR (0.43) | GNRHRALDH1A1BRD4KDM4ENQO2 | |
| SCHEMBL6122986 | 0.89 | PLA2G2A (0.44) | GNRHRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2716751 | 0.89 | PIK3CD (0.42) | GNRHRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2716877 | 0.88 | PIK3CD (0.46) | GNRHRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2717642 | 0.87 | PIK3CD (0.49) | GNRHRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2719964 | 0.86 | ALDH1A1 (0.45) | PIK3CDPIK3CAPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL2718085 | 0.86 | PIK3CD (0.43) | GNRHRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6121709 | 0.86 | PIK3CD (0.44) | GNRHRPIK3CDALDH1A1ATMAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-A2 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151740-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |