SCHEMBL2717484

SCHEMBL2717484

CCO[Si](CCCN)(CCCNc1ccc([N+](=O)[O-])cc1[N+](=O)[O-])OCC

nearest known ligand 0.58

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 7/20 0.58
▸ KDM4E B2RXH2 1/20 0.58
▸ KAT2B Q92831 8/20 0.55
▸ ALDH1A1 P00352 3/20 0.52
▸ POLB P06746 4/20 0.48
▸ PKM P14618 2/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.47
▸ LMNA P02545 1/20 0.47
▸ MAPK1 P28482 1/20 0.47
▸ MEN1 O00255 2/20 0.46
▸ KMT2A Q03164 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29351451 0.86 MAPT (0.63) MAPTKDM4EKAT2BALDH1A1POLB
SCHEMBL303646 0.86 MAPT (0.63) MAPTKDM4EKAT2BALDH1A1POLB
SCHEMBL10622798 0.83 KAT2B (0.72) MAPTKDM4EKAT2BALDH1A1POLB
SCHEMBL2228520 0.82 KAT2B (0.66) MAPTKDM4EKAT2BALDH1A1POLB
SCHEMBL17923845 0.81 KAT2B (0.64) MAPTKDM4EKAT2BALDH1A1POLB
SCHEMBL4557828 0.81 KAT2B (0.64) MAPTKDM4EKAT2BALDH1A1POLB
SCHEMBL2228171 0.81 KAT2B (0.64) MAPTKDM4EKAT2BALDH1A1POLB
SCHEMBL30413993 0.81 KAT2B (0.64) MAPTKDM4EKAT2BALDH1A1POLB
Hydrochloric Acid SCHEMBL4699216 0.80 KAT2B (0.65) MAPTKDM4EKAT2BALDH1A1POLB
Ethylamine SCHEMBL5152975 0.79 MAPT (0.50) MAPTKDM4EKAT2BALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11419809-B2 Hair treatment compositions and methods for treating hair L'OREAL (FR) 2022-08-23 — — US disclosed
US-11324689-B2 Cosmetic compositions containing an alkoxysilane and a silsesquioxane resin L'OREAL (FR) 2022-05-10 — — US disclosed
US-20200405618-A1 HAIR TREATMENT COMPOSITIONS AND METHODS FOR TREATING HAIR L'OREAL (FR) 2020-12-31 — — US disclosed
US-20200246247-A1 COSMETIC COMPOSITIONS CONTAINING AN ALKOXYSILANE AND A SILSESQUIOXANE RESIN L'OREAL (FR) 2020-08-06 — — US disclosed
US-10596100-B2 Cosmetic compositions containing an alkoxysilane and a silsesquioxane resin L'OREAL (FR) 2020-03-24 — — US disclosed
US-10576307-B2 Hair-treatment compositions, methods, and kits for treating hair L'OREAL (FR) 2020-03-03 — — US disclosed
US-10561599-B2 Methods and kits for treating chemically relaxed hair L'OREAL (FR) 2020-02-18 — — US disclosed
WO-2018218007-A1 METHODS AND KITS FOR TREATING CHEMICALLY RELAXED HAIR L'OREAL (FR) 2018-11-29 — — WO disclosed
US-20180339175-A1 HAIR-TREATMENT COMPOSITIONS, METHODS, AND KITS FOR TREATING HAIR L'OREAL (FR) 2018-11-29 — — US disclosed
US-20180338901-A1 METHODS AND KITS FOR TREATING CHEMICALLY RELAXED HAIR L'OREAL (FR) 2018-11-29 — — US disclosed
WO-2012061267-A2 TWO-STEP NAIL POLISH PRODUCT L'OREAL SA (FR) 2012-05-10 — — WO disclosed
WO-2012061265-A2 NITROCELLULOSE-FREE NAIL POLISH COMPOSITIONS L'OREAL S.A. (FR) 2012-05-10 — — WO disclosed
WO-2012055812-A1 COSMETIC COMPOSITION COMPRISING A FATTY-CHAIN ALKOXYSILANE AND AN ANTIDANDRUFF AGENT. L'OREAL (FR) 2012-05-03 — — WO disclosed
WO-2012055805-A1 COSMETIC COMPOSITION COMPRISING A FATTY-CHAIN ALKOXYSILANE AND A SILICEOUS COSMETIC AGENT. L'OREAL (FR) 2012-05-03 — — WO disclosed
WO-2012055807-A1 COSMETIC COMPOSITION COMPRISING A FATTY-CHAIN ALKOXYSILANE AND A CATIONIC POLYMER L'OREAL (FR) 2012-05-03 — — WO disclosed
WO-2012055806-A1 COSMETIC COMPOSITION COMPRISING ONE OR MORE FATTY-CHAIN ALKOXYSILANES AND ONE OR MORE NON-SILICEOUS FATTY SUBSTANCES L'OREAL (FR) 2012-05-03 — — WO disclosed
WO-2012055811-A1 COSMETIC COMPOSITION COMPRISING A FATTY-CHAIN ALKOXYSILANE AND A CATIONIC OR NONIONIC SURFACTANT. L'OREAL (FR) 2012-05-03 — — WO disclosed
WO-2012055809-A1 COSMETIC COMPOSITION COMPRISING A FATTY-CHAIN ALKOXYSILANE, AN ANIONIC SURFACTANT AND A NONIONIC, AMPHOTERIC OR ZWITTERIONIC SURFACTANT L'OREAL (FR) 2012-05-03 — — WO disclosed
US-7740664-B2 Composition comprising at least one silicone compound and at least one organosilane L'OREAL S.A. (FR) 2010-06-22 — — US disclosed
US-20090183320-A1 Composition comprising at least one silicone compound and at least one organosilane L'OREAL S.A. (FR) 2009-07-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10576307-B2 Hair-treatment compositions, methods, and kits for treating hair OTC, TET3, SUCLG1 MAPT 2494/4885KDM4E 1056/4885KAT2B 1063/4885
US-10561599-B2 Methods and kits for treating chemically relaxed hair CRAT, DNMT1, TET3 MAPT 2881/4885KDM4E 489/4885KAT2B 853/4885
US-20180339175-A1 HAIR-TREATMENT COMPOSITIONS, METHODS, AND KITS FOR TREATING HAIR OTC, TET3, SUCLG1 MAPT 2494/4885KDM4E 1056/4885KAT2B 1063/4885
US-10596100-B2 Cosmetic compositions containing an alkoxysilane and a silsesquioxane resin SRM, STS, SMS MAPT 4429/4885KDM4E 926/4885KAT2B 1340/4885
US-11419809-B2 Hair treatment compositions and methods for treating hair TET3, TET1, ALG3 MAPT 2496/4885KDM4E 232/4885KAT2B 804/4885
US-11324689-B2 Cosmetic compositions containing an alkoxysilane and a silsesquioxane resin SRM, STS, SMS MAPT 4429/4885KDM4E 926/4885KAT2B 1340/4885
US-20180338901-A1 METHODS AND KITS FOR TREATING CHEMICALLY RELAXED HAIR CRAT, DNMT1, TET3 MAPT 2881/4885KDM4E 489/4885KAT2B 853/4885
US-20090183320-A1 Composition comprising at least one silicone compound and at least one organosilane KRT18, VIM, SMC4 MAPT 1180/4885KDM4E 370/4885KAT2B 148/4885
US-20200405618-A1 HAIR TREATMENT COMPOSITIONS AND METHODS FOR TREATING HAIR TET3, TET1, ALG3 MAPT 2496/4885KDM4E 232/4885KAT2B 804/4885
US-20200246247-A1 COSMETIC COMPOSITIONS CONTAINING AN ALKOXYSILANE AND A SILSESQUIOXANE RESIN SRM, STS, SMS MAPT 4429/4885KDM4E 926/4885KAT2B 1340/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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