SCHEMBL2717537

SCHEMBL2717537

O=C(COc1cccc(F)c1)N(Cc1cccs1)c1cccnc1

nearest known ligand 0.71

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TRPM8 Q7Z2W7 14/20 0.71
TP53 P04637 5/20 0.57
LMNA P02545 3/20 0.49
THRB P10828 1/20 0.47
TDP1 Q9NUW8 1/20 0.46
POLB P06746 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30582820 1.00 TRPM8 (0.71) TRPM8TP53LMNATHRBTDP1
SCHEMBL2717987 0.89 TRPM8 (0.81) TRPM8TP53LMNATDP1POLB
SCHEMBL30582849 0.88 TRPM8 (0.74) TRPM8TP53LMNATHRBPOLB
SCHEMBL2719236 0.88 TRPM8 (0.80) TRPM8TP53LMNATHRB
SCHEMBL2717851 0.88 TRPM8 (0.74) TRPM8TP53LMNATHRBPOLB
SCHEMBL2720222 0.88 TRPM8 (0.67) TRPM8TP53LMNATHRBTDP1
SCHEMBL2717456 0.88 TRPM8 (0.82) TRPM8TP53LMNATDP1POLB
SCHEMBL30582855 0.88 TRPM8 (0.67) TRPM8TP53LMNATHRBTDP1
Hydrochloric Acid SCHEMBL30582822 0.87 TRPM8 (0.72) TRPM8TP53LMNATHRBPOLB
Hydrochloric Acid SCHEMBL2718171 0.87 TRPM8 (0.72) TRPM8TP53LMNATHRBPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025132323-A1 COMPOSITIONS COMPRISING A SUNSCREEN ACTIVE AGENT DSM-FIRMENICH AG (CH) 2025-06-26 WO disclosed
EP-3470407-B1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED (US) 2024-01-24 EP disclosed
CN-109414048-B Coated yeast formulation 弗门尼舍有限公司 2023-09-01 CN disclosed
EP-3478089-B1 PLATED YEAST FORMULATIONS FIRMENICH & CIE (CH) 2021-11-03 EP disclosed
US-11160894-B2 Perfume emanating device FIRMENICH SA (CH) 2021-11-02 US disclosed
US-11091734-B2 Plated yeast formulations FIRMENICH SA (CH) 2021-08-17 US disclosed
US-10953007-B2 Compounds useful as modulators of TRPM8 FIRMENICH INCORPORATED (US) 2021-03-23 US disclosed
US-10953007-B2 Compounds useful as modulators of TRPM8 FIRMENICH INCORPORATED (US) 2021-03-23 US disclosed
EP-3478089-A1 PLATED YEAST FORMULATIONS Firmenich SA (CH) 2019-05-08 EP disclosed
EP-3470407-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 Senomyx, Inc. (US) 2019-04-17 EP disclosed
US-9394287-B2 Compounds useful as modulators of TRPM8 SENOMYX, INC. (US) 2016-07-19 US disclosed
US-20150313820-A1 PREPARATIONS SYMRISE AG (DE) 2015-11-05 US disclosed
US-20150313820-A1 PREPARATIONS SYMRISE AG (DE) 2015-11-05 US disclosed
US-20130324557-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2013-12-05 US disclosed
EP-2635572-A2 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 Senomyx, Inc. (US) 2013-09-11 EP disclosed
CN-103201279-A Compounds useful as modulators of TRPM8 SENOMYX INC 2013-07-10 CN disclosed
WO-2012061698-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2012-09-13 WO disclosed
WO-2012061698-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2012-09-13 WO disclosed
WO-2012061698-A2 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2012-05-10 WO disclosed
WO-2012061698-A2 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2012-05-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11160894-B2 Perfume emanating device DPM1, SURF4, FAAH2 TRPM8 151/4885TP53 3063/4885LMNA 3524/4885
US-10953007-B2 Compounds useful as modulators of TRPM8 TRPM8, TRPM7, TRPM6 TRPM8 1/4885TP53 4485/4885LMNA 4155/4885
US-20130324557-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM7, TRPM6 TRPM8 1/4885TP53 4485/4885LMNA 4155/4885
US-20150313820-A1 PREPARATIONS CRAT, ACAT2, TAS2R50 TRPM8 101/4885TP53 2706/4885LMNA 1435/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.