SCHEMBL27176261

SCHEMBL27176261

O=C(NCCCCn1ccnc1)c1cc(-c2ccccc2)no1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.65
SMN1; SMN2 Q16637 3/20 0.65
RAB9A P51151 2/20 0.65
HTT P42858 2/20 0.65
NPC1 O15118 1/20 0.65
HIF1A Q16665 1/20 0.65
NAMPT P43490 2/20 0.58
MEN1 O00255 2/20 0.57
KMT2A Q03164 2/20 0.57
TSHR P16473 1/20 0.57
ADRA2A P08913 1/20 0.55
ADRA2B P18089 1/20 0.55
HTR1D P28221 1/20 0.55
HTR1B P28222 1/20 0.55
OPRK1 P41145 1/20 0.55
HTR2B P41595 1/20 0.55
TMEM97 Q5BJF2 1/20 0.55
PAOX Q6QHF9 1/20 0.55
SMOX Q9NWM0 1/20 0.55
ALDH1A1 P00352 5/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17874021 0.97 LMNA (0.69) LMNASMN1; SMN2RAB9AHTTNPC1
SCHEMBL27176283 0.93 LMNA (0.60) LMNASMN1; SMN2RAB9AHTTNPC1
SCHEMBL19756346 0.85 SMN1; SMN2 (0.52) LMNASMN1; SMN2RAB9AHTTNPC1
SCHEMBL27176243 0.82 HDAC1 (0.48) LMNASMN1; SMN2RAB9AHTTNPC1
SCHEMBL1179277 0.79 LMNA (1.00) LMNASMN1; SMN2RAB9AHTTNPC1
SCHEMBL17873980 0.79 SMN1; SMN2 (0.65) LMNASMN1; SMN2RAB9AHTTNPC1
SCHEMBL25576017 0.79 NAAA (0.52) SMN1; SMN2RAB9AHIF1AMEN1KMT2A
SCHEMBL17652562 0.79 HDAC1 (0.54) LMNASMN1; SMN2RAB9AHIF1ANAMPT
SCHEMBL24620722 0.78 NAAA (0.55) SMN1; SMN2RAB9AHIF1AMEN1KMT2A
SCHEMBL27557737 0.77 NPC1 (0.74) SMN1; SMN2NPC1NAMPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240294876-A1 METHODS FOR THE EXPANSION OF HUMAN GRANULOCYTE-MACROPHAGE PROGENITORS AND APPLICATIONS THEREOF UNIV SOUTHERN CALIFORNIA (US) 2024-09-05 US disclosed
EP-4341386-A2 METHODS FOR THE EXPANSION OF HUMAN GRANULOCYTEMACROPHAGE PROGENITORS AND APPLICATIONS THEREOF University of Southern California (US) 2024-03-27 EP disclosed
CN-117751182-A Method for amplifying human granulocyte-macrophage progenitor cells and application thereof 南加利福尼亚大学 2024-03-22 CN disclosed
WO-2022245977-A2 METHODS FOR THE EXPANSION OF HUMAN GRANULOCYTEMACROPHAGE PROGENITORS AND APPLICATIONS THEREOF UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2022-11-24 WO disclosed