Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alpha-Tocopherol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.89 |
| ▸ | TTPA | P49638 | 3/20 | 0.89 |
| ▸ | MAPT | P10636 | 2/20 | 0.89 |
| ▸ | MEN1 | O00255 | 2/20 | 0.89 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.89 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.89 |
| ▸ | USP2 | O75604 | 1/20 | 0.89 |
| ▸ | THRB | P10828 | 1/20 | 0.89 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.89 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.89 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.81 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.81 |
| ▸ | PDE4A | P27815 | 1/20 | 0.73 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.73 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.70 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.67 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.67 |
| ▸ | AKT1 | P31749 | 2/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | PHLPP1 | O60346 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alpha-Tocopherol SCHEMBL28174566 | 1.00 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL28174565 | 1.00 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL27538180 | 1.00 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL4083978 | 1.00 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tochopherol SCHEMBL1879635 | 1.00 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL5868266 | 0.99 | LMNA (0.88) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL28110607 | 0.96 | LMNA (0.82) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL4556023 | 0.96 | LMNA (0.82) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL27696980 | 0.96 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL359184 | 0.95 | LMNA (0.84) | LMNATTPAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 38271 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4746844-A1 | PERSONAL CARE COMPOSITIONS | Colgate-Palmolive Company (US) | 2026-05-27 | — | — | EP | claimed |
| US-12636309-B2 | Storage stable formulations of sulfated glycosaminoglycans and fragments derived therefrom for the treatment of pain and other medical conditions | ADORA ANIMAL HEALTH CORPORATION (US) | 2026-05-26 | — | — | US | claimed |
| US-12636308-B2 | Storage stable formulations of sulfated glycosaminoglycans and fragments derived therefrom for the treatment of pain and other medical conditions | ADORA ANIMAL HEALTH CORPORATION (US) | 2026-05-26 | — | — | US | claimed |
| EP-4745225-A1 | SERUM-FREE NUTRIENT COMPOSITION FOR THE CULTIVATION OF VERTEBRATE CELLS | The Cultivated B. GmbH (DE) | 2026-05-20 | — | — | EP | claimed |
| EP-3313534-B1 | SUPERABSORBENT POLYMERS AND STARCH POWDERS FOR USE IN SKIN CARE COMPOSITIONS | PROCTER & GAMBLE (US) | 2026-05-20 | — | — | EP | claimed |
| CN-122056817-A | Oil-pearl type composition for skin and preparation method and application thereof | 广州科思生物科技有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122031325-A | Pure sunscreen lotion suitable for sensitive muscles and preparation method thereof | 上海美浮特生物科技有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122031322-A | Plant composition for resisting photo-thermal injury and realizing anti-inflammatory repair and application thereof | 青漾时光(武汉)生物科技有限公司 | 2026-05-15 | — | — | CN | claimed |
| EP-4741020-A1 | NANO PROTECTOR FORMULATION BASED ON HYALURONIC ACID AND AMINO ACIDS FOR SKIN CARE AND REPAIR | Bionano Research, S.A. De C.V. (MX) | 2026-05-13 | — | — | EP | claimed |
| CN-122005332-A | Bionic self-assembled biphasic sugar ester mask with extremely simple process and preparation method thereof | 中山中研化妆品有限公司 | 2026-05-12 | — | — | CN | claimed |
| EP-0147446-A4 | IMPROVED COMPOSITIONS FOR THE TREATMENT OF PSORIASIS. | STIEFEL LABORATORIES (US) | 1987-04-29 | — | — | EP | claimed |
| WO-1987001035-A1 | PHARMACEUTICAL MICROEMULSIONS | CALIFORNIA BIOTECHNOLOGY INC. (US) | 1987-02-26 | — | — | WO | claimed |
| US-4639533-A | TRIMETHYLHYDROQUINONE, PHYTYL DERIVATIVE | BASF CORPORATION (US) | 1987-01-27 | — | — | US | claimed |
| US-4634781-A | AMINE SALT OF NON-OXIDIZING ACID | BASF CORPORATION (US) | 1987-01-06 | — | — | US | claimed |
| EP-0100471-B1 | ALPHA TOCOPHEROL PROCESS | BASF Corporation (US) | 1986-10-22 | — | — | EP | claimed |
| US-4551480-A | ANTHRALIN, WATER IN OIL HYDROCARBON EMULSION, ANIONIC SURFACTANT AND ANTIOXIDANT | STIEFEL LABORATORIES, INC. (US) | 1985-11-05 | — | — | US | claimed |
| EP-0147446-A1 | IMPROVED COMPOSITIONS FOR THE TREATMENT OF PSORIASIS | STIEFEL LABORATORIES, INC. (US) | 1985-07-10 | — | — | EP | claimed |
| WO-1985000106-A1 | IMPROVED COMPOSITIONS FOR THE TREATMENT OF PSORIASIS | STIEFEL LABORATORIES, INC. (US) | 1985-01-17 | — | — | WO | claimed |
| EP-0100471-A1 | Alpha tocopherol process | BASF Corporation (US) | 1984-02-15 | — | — | EP | claimed |
| US-4410517-A | SEXUAL LUBRICANT | STILLMAN THEODORE | 1983-10-18 | — | — | US | claimed |