Alpha-Tocopherol

Alpha-Tocopherol

SCHEMBL359184

CC(C(=O)O)=C(C)C(=O)O.Cc1c(C)c2c(c(C)c1O)CC[C@@](C)(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)O2

nearest known ligand 0.84

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.84
TTPA P49638 3/20 0.84
MAPT P10636 2/20 0.84
MEN1 O00255 2/20 0.84
KMT2A Q03164 2/20 0.84
GSTP1 P09211 1/20 0.84
USP2 O75604 1/20 0.84
THRB P10828 1/20 0.84
CYP2C9 P11712 1/20 0.84
CYP2C19 P33261 1/20 0.84
ALOX5 P09917 3/20 0.76
NR1I2 O75469 2/20 0.76
PDE4A P27815 1/20 0.69
PDE3A Q14432 1/20 0.69
PSEN1 P49768 2/20 0.67
GSTO1 P78417 2/20 0.64
PTPN1 P18031 1/20 0.64
AKT1 P31749 2/20 0.50
PDPK1 O15530 1/20 0.50
PHLPP1 O60346 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alpha-Tochopherol SCHEMBL1879635 0.95 LMNA (0.89) LMNATTPAMAPTMEN1KMT2A
Alpha-Tocopherol SCHEMBL28174565 0.95 LMNA (0.89) LMNATTPAMAPTMEN1KMT2A
Alpha-Tocopherol SCHEMBL28174566 0.95 LMNA (0.89) LMNATTPAMAPTMEN1KMT2A
Alpha-Tocopherol SCHEMBL4083978 0.95 LMNA (0.89) LMNATTPAMAPTMEN1KMT2A
Alpha-Tocopherol SCHEMBL27177 0.95 LMNA (0.89) LMNATTPAMAPTMEN1KMT2A
Alpha-Tocopherol SCHEMBL27538180 0.95 LMNA (0.89) LMNATTPAMAPTMEN1KMT2A
Alpha-Tocopherol SCHEMBL27696980 0.95 LMNA (0.89) LMNATTPAMAPTMEN1KMT2A
Alpha-Tocopherol SCHEMBL5868266 0.94 LMNA (0.88) LMNATTPAMAPTMEN1KMT2A
Alpha-Tocopherol SCHEMBL7074016 0.93 LMNA (0.82) LMNATTPAMAPTMEN1KMT2A
Alpha-Tocopherol SCHEMBL460611 0.92 LMNA (0.88) LMNATTPAMAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10668029-B2 Compositions containing non-polar compounds VIRUN, INC. (US) 2020-06-02 US disclosed
US-10335385-B2 Composition containing non-polar compounds VIRUN, INC. (US) 2019-07-02 US disclosed
US-10285971-B2 Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same VIRUN, INC. (US) 2019-05-14 US disclosed
US-10220007-B2 Compositions containing non-polar compounds VIRUN, INC. (US) 2019-03-05 US disclosed
US-20180098962-A1 FORMULATIONS OF WATER-SOLUBLE DERIVATIVES OF VITAMIN E AND SOFT GEL COMPOSITIONS, CONCENTRATES AND POWDERS CONTAINING SAME VIRUN, INC. 2018-04-12 US disclosed
US-20180042865-A1 COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS VIRUN, INC. 2018-02-15 US disclosed
US-9861611-B2 Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same VIRUN, INC. (US) 2018-01-09 US disclosed
US-9788564-B2 Compositions containing non-polar compounds VIRUN, INC. (US) 2017-10-17 US disclosed
US-9693574-B2 Compositions containing water-soluble derivatives of vitamin E mixtures and modified food starch VIRUN, INC. (US) 2017-07-04 US disclosed
US-20170182133-A1 COMPOSITIONS FOR PROVIDING AGENTS THAT DEGRADE IN WATER VIRUN, INC. 2017-06-29 US disclosed
US-20120016026-A1 Compositions containing non-polar compounds VIRUN, INC. 2012-01-19 US disclosed
WO-2011162802-A1 COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS VIRUN, INC. (US) 2011-12-29 WO disclosed
WO-2011119228-A1 NANOEMULSION INCLUDING SUCROSE FATTY ACID ESTER VIRUN, INC. (US) 2011-09-29 WO disclosed
US-20110236364-A1 Compositions containing non-polar compounds VIRUN, INC. 2011-09-29 US disclosed
EP-2268160-A1 EMULSIONS INCLUDING A PEG-DERIVATIVE OF TOCOPHEROL Virun, Inc. (US) 2011-01-05 EP disclosed
US-20100041622-A1 Compositions containing aminoalkanes and aminoalkane derivatives VIRUN, INC. 2010-02-18 US disclosed
WO-2010019255-A1 COMPOSITIONS CONTAINING AMINOALKANES AND AMINOALKANE DERIVATIVES VIRUN, INC. (US) 2010-02-18 WO disclosed
US-20090297665-A1 Compositions containing non-polar compounds VIRUN, INC. 2009-12-03 US disclosed
US-20090297491-A1 Compositions containing non-polar compounds VIRUN, INC. 2009-12-03 US disclosed
WO-2009117152-A1 EMULSIONS INCLUDING A PEG-DERIVATIVE OF TOCOPHEROL VIRUN, INC. (US) 2009-09-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180042865-A1 COMPOSITIONS CONTAINING NON-POLAR COMPOUNDS ELOVL6, ELOVL3, ELOVL5 LMNA 800/4885TTPA 117/4885MAPT 1511/4885
US-10335385-B2 Composition containing non-polar compounds ELOVL6, ELOVL3, ELOVL1 LMNA 302/4885TTPA 15/4885MAPT 1498/4885
US-20110236364-A1 Compositions containing non-polar compounds ELOVL6, ELOVL3, ELOVL5 LMNA 738/4885TTPA 117/4885MAPT 1004/4885
US-20100041622-A1 Compositions containing aminoalkanes and aminoalkane derivatives TAAR5, PDE3A, PDE2A LMNA 1572/4885TTPA 750/4885MAPT 3026/4885
US-10285971-B2 Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same TTPA, PTGES, HPGDS LMNA 1169/4885TTPA 1/4885MAPT 1624/4885
US-20090297491-A1 Compositions containing non-polar compounds ELOVL6, ELOVL3, ELOVL5 LMNA 800/4885TTPA 117/4885MAPT 1511/4885
US-20180098962-A1 FORMULATIONS OF WATER-SOLUBLE DERIVATIVES OF VITAMIN E AND SOFT GEL COMPOSITIONS, CONCENTRATES AND POWDERS CONTAINING SAME TTPA, PTGES, HPGDS LMNA 1169/4885TTPA 1/4885MAPT 1624/4885
US-20170182133-A1 COMPOSITIONS FOR PROVIDING AGENTS THAT DEGRADE IN WATER MUC1, MMP7, MMP1 LMNA 2010/4885TTPA 235/4885MAPT 3661/4885
US-20120016026-A1 Compositions containing non-polar compounds ELOVL6, ELOVL3, ELOVL5 LMNA 282/4885TTPA 11/4885MAPT 1565/4885
US-10220007-B2 Compositions containing non-polar compounds ELOVL6, ELOVL3, ELOVL5 LMNA 800/4885TTPA 117/4885MAPT 1511/4885
US-10668029-B2 Compositions containing non-polar compounds ELOVL6, ELOVL3, ELOVL5 LMNA 800/4885TTPA 117/4885MAPT 1511/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.