Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Alpha-Tocopherol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.82 |
| ▸ | TTPA | P49638 | 3/20 | 0.82 |
| ▸ | MAPT | P10636 | 2/20 | 0.82 |
| ▸ | MEN1 | O00255 | 2/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.82 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.82 |
| ▸ | USP2 | O75604 | 1/20 | 0.82 |
| ▸ | THRB | P10828 | 1/20 | 0.82 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.82 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.75 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.75 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.73 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.73 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.68 |
| ▸ | PDE4A | P27815 | 1/20 | 0.68 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.68 |
| ▸ | AKT1 | P31749 | 2/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | PHLPP1 | O60346 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alpha-Tocopherol SCHEMBL28110607 | 1.00 | LMNA (0.82) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL42939 | 0.98 | LMNA (0.86) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL27995975 | 0.98 | LMNA (0.86) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL28174566 | 0.96 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL28174565 | 0.96 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tochopherol SCHEMBL1879635 | 0.96 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL4083978 | 0.96 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL27177 | 0.96 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL27538180 | 0.96 | LMNA (0.89) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL27991376 | 0.95 | LMNA (0.81) | LMNATTPAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2043628-A2 | ULTRAVIOLET ABSORBING OPHTHALMIC COMPOSITIONS | Riolan Technologies, Inc. (US) | 2009-04-08 | — | — | EP | claimed |
| US-20080015250-A1 | Ultraviolet absorbing ophthalmic compositions | RIOLAN TECHNOLOGIES, INC. | 2008-01-17 | — | — | US | claimed |
| WO-2008002582-A2 | ULTRAVIOLET ABSORBING OPHTHALMIC COMPOSITIONS | RIOLAN TECHNOLOGIES, INC. (US) | 2008-01-03 | — | — | WO | claimed |
| CN-101889982-B | Novel long-circulating liposome composition and preparation method thereof | JEWIM PHARMACEUTICAL SHANDONG CO LTD | 2012-12-26 | — | — | CN | disclosed |
| CN-101889982-A | Novel long-circulating liposome composition and preparation method thereof | JEWIM PHARMACEUTICAL SHANDONG CO LTD | 2010-11-24 | — | — | CN | disclosed |
| EP-2043628-A2 | ULTRAVIOLET ABSORBING OPHTHALMIC COMPOSITIONS | Riolan Technologies, Inc. (US) | 2009-04-08 | — | — | EP | disclosed |
| US-20080015250-A1 | Ultraviolet absorbing ophthalmic compositions | RIOLAN TECHNOLOGIES, INC. | 2008-01-17 | — | — | US | disclosed |
| WO-2008002582-A2 | ULTRAVIOLET ABSORBING OPHTHALMIC COMPOSITIONS | RIOLAN TECHNOLOGIES, INC. (US) | 2008-01-03 | — | — | WO | disclosed |