Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2718834 | 0.91 | PARP1 (0.41) | CYP3A4CYP1A2CYP2D6NR4A2MAPT | |
| SCHEMBL2720019 | 0.85 | GRM5 (0.40) | KMT2AMEN1FERMT2 | |
| SCHEMBL2718503 | 0.81 | ERN1 (0.42) | CYP1A2ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL11467991 | 0.80 | CYP1A2 (0.45) | CYP3A4CYP1A2CYP2D6ALDH1A1NR4A2 | |
| SCHEMBL11472817 | 0.79 | CYP3A4 (0.44) | CYP3A4CYP1A2CYP2D6ALDH1A1NR4A2 | |
| SCHEMBL2718102 | 0.76 | PARP1 (0.39) | ALDH1A1PARP1 | |
| SCHEMBL529686 | 0.76 | CYP1A2 (0.40) | CYP3A4CYP1A2CYP2D6ALDH1A1MAPT | |
| SCHEMBL18283397 | 0.73 | CYP1A2 (0.38) | CYP3A4CYP1A2CYP2D6ALDH1A1NR4A2 | |
| SCHEMBL18283403 | 0.72 | ALDH1A1 (0.50) | CYP3A4CYP1A2CYP2D6ALDH1A1NR4A2 | |
| SCHEMBL11477650 | 0.70 | NR4A2 (0.43) | CYP3A4CYP1A2CYP2D6NR4A2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635565-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | Amgen Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |