Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GPR3 | P46089 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2718834 | 0.84 | PARP1 (0.41) | KDM4ECYP1A2MEN1MAPTKMT2A | |
| SCHEMBL26324062 | 0.81 | MAOA (0.45) | ERN1MAOAMAOBKDM4EGPR3 | |
| SCHEMBL2717954 | 0.81 | CYP3A4 (0.41) | KDM4EALOX15ALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL11069135 | 0.79 | MAOA (0.47) | ERN1MAOAMAOBKDM4EGPR3 | |
| SCHEMBL844114 | 0.79 | MAOA (0.47) | ERN1MAOAMAOBKDM4EGPR3 | |
| SCHEMBL2720019 | 0.78 | GRM5 (0.40) | MEN1KMT2A | |
| SCHEMBL2718102 | 0.78 | PARP1 (0.39) | ALDH1A1PARP1SMN1; SMN2 | |
| SCHEMBL529686 | 0.78 | CYP1A2 (0.40) | KDM4EALDH1A1HPGDCYP1A2CYP2C9 | |
| SCHEMBL2720224 | 0.78 | PADI4 (0.44) | ERN1KDM4EGPR3ALDH1A1HPGD | |
| SCHEMBL2717724 | 0.78 | HAVCR2 (0.42) | KDM4EPDE4BPDE4DALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635565-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | Amgen Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |