Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 2/20 | 0.49 |
| ▸ | METAP1 | P53582 | 2/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 2/20 | 0.37 |
| ▸ | CCR5 | P51681 | 2/20 | 0.37 |
| ▸ | CCR8 | P51685 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2320187 | 0.83 | KDM4E (0.47) | METAP1METAP2KDM4ETDP1LMNA | |
| SCHEMBL10462546 | 0.77 | BACE1 (0.42) | KDM4ELMNAL3MBTL1NPC1CYP1A2 | |
| SCHEMBL15831591 | 0.72 | METAP1 (0.54) | CBFBMETAP1METAP2GRM5KDM4E | |
| SCHEMBL22238047 | 0.71 | METAP2 (0.49) | CBFBMETAP1METAP2GRM5KDM4E | |
| SCHEMBL15229223 | 0.69 | ALDH1A1 (0.43) | KDM4ENPC1POLBTP53HSP90AA1 | |
| SCHEMBL1780817 | 0.68 | KDM4E (0.45) | CBFBMETAP1METAP2GRM5KDM4E | |
| SCHEMBL7549266 | 0.68 | CCR1 (0.64) | CBFBMETAP1METAP2GRM5KDM4E | |
| SCHEMBL20067937 | 0.68 | PIK3CD (0.58) | CBFBMETAP1METAP2GRM5KDM4E | |
| SCHEMBL4757272 | 0.67 | KDM4E (0.40) | KDM4ECYP1A2 | |
| SCHEMBL11160532 | 0.67 | PDGFRB (0.38) | GRM5NPC1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-A2 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151740-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |