Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL27206956 | 0.98 | KDM4E (0.38) | KDM4EBLMALOX15PRMT5WDR77 | |
| Citric Acid SCHEMBL27199902 | 0.98 | KDM4E (0.38) | KDM4EBLMALOX15PRMT5WDR77 | |
| Acetic Acid SCHEMBL27199898 | 0.88 | KDM4E (0.43) | KDM4EBLMALOX15PRMT5WDR77 | |
| Citric Acid SCHEMBL27199947 | 0.86 | KDM4E (0.42) | KDM4EBLMALOX15 | |
| Citric Acid SCHEMBL31344188 | 0.84 | KDM4E (0.43) | KDM4EBLMALOX15 | |
| Citric Acid SCHEMBL27199869 | 0.84 | KDM4E (0.43) | KDM4EBLMALOX15 | |
| Citric Acid SCHEMBL27200148 | 0.84 | KDM4E (0.43) | KDM4EBLMALOX15 | |
| Levulinic Acid SCHEMBL27199853 | 0.82 | KDM4E (0.38) | KDM4EBLMALOX15PRMT5WDR77 | |
| Citric Acid SCHEMBL27199861 | 0.82 | GRM5 (0.38) | KDM4EBLM | |
| Citric Acid SCHEMBL27199913 | 0.81 | CHRNB4 (0.45) | KDM4EBLMALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11964958-B1 | Vaporizable alkaloid compositions and methods of use thereof | Ready Mix Naturals, LLC (US) | 2024-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11964958-B1 | Vaporizable alkaloid compositions and methods of use thereof | SRM, SCLY, SMOX | KDM4E 812/4885BLM 3053/4885ALOX15 4144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.