SMOX — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL16995667	0.72	3/20
SCHEMBL18353510	0.66	3/20
SCHEMBL16995714	0.64	3/20
SCHEMBL17741702	0.59	3/20
SCHEMBL16995650	0.57	3/20
SCHEMBL16995649	0.55	3/20
SCHEMBL17741890	0.55	3/20
SCHEMBL17742100	0.55	3/20
SCHEMBL17742104	0.53	3/20
SCHEMBL9818908	0.53	3/20
SCHEMBL10433765	0.49	3/20
SCHEMBL17741783	0.48	3/20
SCHEMBL26662268	0.47	3/20
SCHEMBL17741878	0.55	2/20
SCHEMBL14452021	0.54	2/20
SCHEMBL2462712	0.53	2/20
SCHEMBL16995651	0.52	2/20
SCHEMBL16995691	0.52	2/20
SCHEMBL18353620	0.52	2/20
SCHEMBL112755	0.51	2/20

Clinical trials — most relevant to SMOX by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Role of Antioxidants Supplementation in Chronic Pancreatitis	PHASE3	COMPLETED
Comparison of Acetyl- L- Carnitine& Folic Acid Versus Coenzyme Q10& Folic Acid on Semen& Hormonal Parameters& Semen Oxidative Status in Patients of Primary Infertility. A Double Blind Randomized Clinical Trial	PHASE2	COMPLETED
L-carnitine Supplementation in Rheumatoid Arthritis Patients	PHASE2	RECRUITING
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old	PHASE2	ACTIVE_NOT_RECRUITING
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia	PHASE1/PHASE2	COMPLETED
GSNOR Phenotyping/GSNO Challenge in Severe Asthma	EARLY_PHASE1	COMPLETED
Uterine Artery Doppler Changes After Vaginal Administration of Isosorbide Mononitrate In Patients With URPL	EARLY_PHASE1	UNKNOWN
iNOS With Positron Emission Tomography (PET) in Cellular Inflammation.	EARLY_PHASE1	COMPLETED
External Nitric Oxide Measurement Through SNO Degradation	nan	ENROLLING_BY_INVITATION
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
Study the Effect of Oral Zinc Supplementation on Enzymes of Nitric Oxide Pathway	nan	COMPLETED
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart	nan	UNKNOWN
Characterization of the Pharmacokinetics of Oral Selenium Compounds in Humans Before and Following Supplementation	nan	COMPLETED
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED
Egg Intake, Metabolic Outcomes and Choline Levels	nan	RECRUITING
Dietary Effects of Sulfur Amino Acids	nan	COMPLETED
Comparison of ICSI Outcomes in Cycles Using Testicular and Ejaculate Sperm From Couples With High SDF	nan	COMPLETED
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD	nan	UNKNOWN
Molecular Markers of Human Sperm Function	nan	WITHDRAWN
Epididymal U.S Findings in Asthenozoospermic &Correlation With L.Carnitine Level	nan	UNKNOWN
S-adenosylmethionine Plus Choline in Treatment of Patients With Alcoholic Liver Disease	nan	UNKNOWN
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Modulation of Genes Responsible for Cilia Length by Exposure to Cigarette Smoke	nan	COMPLETED
Effect of Supplementary Vitamins on Oxidant Gene Expression in the Lungs of Healthy Smokers	nan	COMPLETED
Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC	nan	COMPLETED
Impact Of Choline in Patients With NAFLD	nan	UNKNOWN
Is Pentoxifylline Able to Improve Olfactory Sensitivity?	nan	COMPLETED
Primary Hyperoxaluria Mutation Genotyping/Phenotyping	nan	COMPLETED
Genetic Mechanisms of Chronic Obstructive Pulmonary Disease (COPD)	nan	COMPLETED
Promotion of Weight Management	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a SMOX binder may also engage these)

Protein	Name	Similarity
Q99K82	—	1.000	Q99K82 →
Q0J954	—	0.997	Q0J954 →
Q9SKX5	—	0.995	Q9SKX5 →
Q8H191	—	0.995	Q8H191 →
P18487	—	0.995	P18487 →
Q7XR46	—	0.994	Q7XR46 →
Q9LYT1	—	0.994	Q9LYT1 →
Q6YYZ1	—	0.993	Q6YYZ1 →
IL4I1	L-amino-acid oxidase	0.992	landscape →
KDM1A	Lysine-specific histone demethylase 1A	0.992	landscape →
O09046	—	0.991	O09046 →
Q5XI69	—	0.990	Q5XI69 →
Q5BJS0	—	0.990	Q5BJS0 →
Q9SU79	—	0.990	Q9SU79 →
F4IDQ6	—	0.990	F4IDQ6 →
KDM1B	Lysine-specific histone demethylase 2	0.990	landscape →
Q6ZQ88	—	0.990	Q6ZQ88 →
Q6TGQ8	—	0.990	Q6TGQ8 →
O96566	—	0.989	O96566 →
Q7X809	—	0.989	Q7X809 →
Q6PE54	—	0.989	Q6PE54 →
D3ZEY4	—	0.989	D3ZEY4 →
Q8CIG3	—	0.989	Q8CIG3 →
Q9LID0	—	0.989	Q9LID0 →
Q5R607	—	0.988	Q5R607 →
P0CC17	—	0.988	P0CC17 →
DHX30	ATP-dependent RNA helicase DHX30	0.988	landscape →
Q4JHE2	—	0.988	Q4JHE2 →
B4NBB0	—	0.988	B4NBB0 →
KDM5D	Lysine-specific demethylase 5D	0.987	landscape →