Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 15/20 | 1.00 |
| ▸ | CTSB | P07858 | 14/20 | 1.00 |
| ▸ | CTSS | P25774 | 14/20 | 1.00 |
| ▸ | CTSK | P43235 | 12/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7804136 | 0.92 | CTSS (1.00) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3417590 | 0.91 | CTSL (0.84) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3419854 | 0.89 | CTSL (0.79) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3420426 | 0.88 | CTSL (0.86) | CTSLCTSBCTSSCTSK | |
| SCHEMBL7797585 | 0.87 | CTSL (0.77) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3476052 | 0.86 | CTSL (0.83) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3422345 | 0.86 | CTSL (0.83) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3419285 | 0.85 | CTSS (0.86) | CTSLCTSBCTSSCTSK | |
| SCHEMBL1273075 | 0.84 | CTSS (0.91) | CTSLCTSBCTSSCTSK | |
| SCHEMBL1273076 | 0.84 | CTSS (0.91) | CTSLCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445872-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF VARIOUS DISEASES | Merck Canada Inc. (CA) | 2012-05-02 | — | — | EP | disclosed |
| US-20120101053-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF VARIOUS DISEASES | MERCK CANADA INC. (CA) | 2012-04-26 | — | — | US | disclosed |
| US-20120101053-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF VARIOUS DISEASES | MERCK CANADA INC. (CA) | 2012-04-26 | — | — | US | disclosed |
| WO-2010148488-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF VARIOUS DISEASES | MERCK FROSST CANADA LTD. (CA) | 2010-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101053-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF VARIOUS DISEASES | CTSL, CTSS, CTSZ | CTSL 1/4885CTSB 5/4885CTSS 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.