SCHEMBL27201412

SCHEMBL27201412

Nc1cc(N2CCCC(n3ncc4ccccc43)C2)nc(N)n1

nearest known ligand 0.41

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 14/20 0.41
FAAH O00519 2/20 0.40
SCD O00767 1/20 0.39
KDM5A P29375 1/20 0.39
HRH3 Q9Y5N1 1/20 0.39
USP2 O75604 1/20 0.38
LMNA P02545 1/20 0.38
TSHR P16473 1/20 0.38
HTT P42858 1/20 0.38
HSD17B10 Q99714 1/20 0.38
NUDT1 P36639 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30834121 1.00 HRH4 (0.41) HRH4FAAHSCDKDM5AHRH3
SCHEMBL30885265 0.87 NUDT1 (0.53) HRH4FAAHSCDKDM5AHRH3
SCHEMBL27201344 0.87 NUDT1 (0.53) HRH4FAAHSCDKDM5AHRH3
SCHEMBL30834173 0.77 HRH4 (0.46) HRH4FAAHHRH3USP2LMNA
SCHEMBL27201352 0.77 HRH4 (0.46) HRH4FAAHHRH3USP2LMNA
SCHEMBL30834075 0.74 CHRM2 (0.49) FAAH
SCHEMBL27201378 0.74 CHRM2 (0.49) FAAH
SCHEMBL29303151 0.72 DDB1 (0.50) SCDKDM5ATSHR
SCHEMBL31495775 0.72 DDB1 (0.50) SCDKDM5ATSHR
SCHEMBL5821024 0.72 HRH4 (0.42) HRH4LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240132464-A1 HETEROCYCLIC COMPOUNDS AS E3 LIGASE INHIBITORS ACCUTAR BIOTECHNOLOGY INC. (US) 2024-04-25 US claimed
US-20240132464-A1 HETEROCYCLIC COMPOUNDS AS E3 LIGASE INHIBITORS ACCUTAR BIOTECHNOLOGY INC. (US) 2024-04-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240132464-A1 HETEROCYCLIC COMPOUNDS AS E3 LIGASE INHIBITORS GID4, MDM2, XIAP HRH4 4074/4885FAAH 4327/4885SCD 2441/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.