Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 4/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.43 |
| ▸ | WNT1 | P04628 | 4/20 | 0.43 |
| ▸ | JAK2 | O60674 | 6/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.36 |
| ▸ | CLK2 | P49760 | 3/20 | 0.36 |
| ▸ | PLK4 | O00444 | 2/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | MARK3 | P27448 | 2/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27201405 | 0.81 | DYRK1A (0.67) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL27201494 | 0.73 | DYRK1A (0.56) | MAP4K4DYRK1AWNT1PDPK1CLK2 | |
| SCHEMBL30834135 | 0.73 | DYRK1A (0.56) | MAP4K4DYRK1AWNT1PDPK1CLK2 | |
| SCHEMBL26889247 | 0.71 | CCNK (0.54) | MAP4K4DYRK1AWNT1JAK2PIM1 | |
| SCHEMBL27201421 | 0.69 | DYRK1A (0.50) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL30885290 | 0.67 | PRKD3 (0.45) | MAP4K4DYRK1AWNT1JAK2CLK2 | |
| SCHEMBL29122272 | 0.66 | CFD (0.46) | JAK2 | |
| SCHEMBL30834169 | 0.66 | CHEK2 (0.47) | MAP4K4DYRK1AWNT1JAK2TYK2 | |
| SCHEMBL30834072 | 0.66 | CLK1 (0.55) | MAP4K4DYRK1AJAK2PIM1PIM3 | |
| SCHEMBL27201611 | 0.66 | CLK1 (0.55) | MAP4K4DYRK1AJAK2PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240132464-A1 | HETEROCYCLIC COMPOUNDS AS E3 LIGASE INHIBITORS | ACCUTAR BIOTECHNOLOGY INC. (US) | 2024-04-25 | — | — | US | claimed |
| WO-2024073502-A1 | HETEROCYCLIC COMPOUNDS AS E3 LIGASE INHIBITORS | ACCUTAR BIOTECHNOLOGY INC. (US) | 2024-04-04 | — | — | WO | claimed |
| US-20240132464-A1 | HETEROCYCLIC COMPOUNDS AS E3 LIGASE INHIBITORS | ACCUTAR BIOTECHNOLOGY INC. (US) | 2024-04-25 | — | — | US | disclosed |
| WO-2024073502-A1 | HETEROCYCLIC COMPOUNDS AS E3 LIGASE INHIBITORS | ACCUTAR BIOTECHNOLOGY INC. (US) | 2024-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240132464-A1 | HETEROCYCLIC COMPOUNDS AS E3 LIGASE INHIBITORS | GID4, MDM2, XIAP | MAP4K4 1878/4885DYRK1A 2404/4885WNT1 689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.