Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 7/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25931657 | 0.81 | CHEK2 (0.59) | CHEK2GRIN1GRIN2BCYP1A2CYP2E1 | |
| SCHEMBL12909164 | 0.81 | ALDH1A1 (0.63) | CHEK2GRIN1GRIN2BCYP1A2CYP2E1 | |
| SCHEMBL7808795 | 0.80 | GRIN1 (0.62) | CHEK2GRIN1GRIN2BCYP1A2CYP2E1 | |
| SCHEMBL4825999 | 0.79 | CYP3A4 (0.54) | CHEK2CYP1A2CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL26189984 | 0.78 | NPC1 (0.40) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL916533 | 0.78 | NPC1 (0.58) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL29770426 | 0.78 | NPC1 (0.58) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL11191139 | 0.78 | MAOB (0.46) | CHEK2GRIN1GRIN2BKDM4ENPC1 | |
| SCHEMBL24953738 | 0.77 | KDM4E (0.60) | CHEK2GRIN1GRIN2BCYP1A2CYP2E1 | |
| SCHEMBL7807073 | 0.77 | GRIN1 (0.62) | CHEK2GRIN1GRIN2BCYP1A2CYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240132479-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2024-04-25 | — | — | US | disclosed |
| WO-2022165198-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2022-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240132479-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | CUTA, DCXR, PLOD3 | CHEK2 3840/4885GRIN1 4482/4885GRIN2B 4451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.