SCHEMBL27204002

SCHEMBL27204002

NC(=O)c1cnc2c(c1)nc(N)n2C/C=C/CNC(=O)O

nearest known ligand 0.41

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ STING1 Q86WV6 9/20 0.41
▸ ADORA2A P29274 1/20 0.35
▸ KMT2A Q03164 1/20 0.32
▸ AKT1 P31749 2/20 0.32
▸ AKT2 P31751 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27207460 1.00 STING1 (0.41) STING1ADORA2AKMT2AAKT1AKT2
SCHEMBL21620360 0.89 STING1 (0.42) STING1ADORA2AKMT2A
Bromide SCHEMBL21616426 0.88 STING1 (0.41) STING1ADORA2AKMT2A
SCHEMBL21620363 0.87 STING1 (0.39) STING1ADORA2A
SCHEMBL21620380 0.85 DRD3 (0.39) STING1ADORA2A
SCHEMBL21616395 0.85 STING1 (0.47) STING1ADORA2A
SCHEMBL21616424 0.84 STING1 (0.41) STING1ADORA2A
SCHEMBL19436528 0.81 KMT2A (0.50) KMT2A
SCHEMBL19436567 0.81 KMT2A (0.50) KMT2A
SCHEMBL21643845 0.80 STING1 (0.42) STING1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240132493-A1 IMIDAZOPYRIDINE DERIVATIVES AS STING AGONISTS FULGENT GENETICS INC (US) 2024-04-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240132493-A1 IMIDAZOPYRIDINE DERIVATIVES AS STING AGONISTS STING1, IRF3, MAVS STING1 1/4885ADORA2A 604/4885KMT2A 3035/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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