⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969262 | 0.67 | — | — | |
| SCHEMBL5155602 | 0.66 | BCAT2 (0.45) | — | |
| Hydrochloric Acid SCHEMBL3963502 | 0.65 | — | — | |
| SCHEMBL9107642 | 0.65 | CYP1A2 (0.59) | — | |
| SCHEMBL3822832 | 0.63 | ALPL (0.57) | — | |
| SCHEMBL19641487 | 0.61 | — | — | |
| SCHEMBL27571730 | 0.61 | ALPL (0.48) | — | |
| SCHEMBL3224791 | 0.60 | — | — | |
| SCHEMBL30332207 | 0.60 | — | — | |
| Pyrrole SCHEMBL18797670 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3760625-B1 | BICYCLIC LACTAMS AS RECEPTOR-INTERACTING PROTEIN-1 (RIP1) KINASE INHIBITORS FOR TREATING E.G. INFLAMMATORY DISEASES | HOFFMANN LA ROCHE (CH) | 2024-03-27 | — | — | EP | disclosed |