Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27203904 | 1.00 | PBRM1 (0.46) | PBRM1ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL27203856 | 1.00 | PBRM1 (0.46) | PBRM1ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL9818910 | 0.84 | PBRM1 (0.51) | PBRM1ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL27203906 | 0.80 | BRD4 (0.44) | PBRM1ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL25207401 | 0.73 | KDM4E (0.47) | PBRM1ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL9819147 | 0.73 | PBRM1 (0.46) | PBRM1ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL30964228 | 0.71 | BRD4 (0.45) | PBRM1ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL7609607 | 0.71 | BRD4 (0.45) | PBRM1ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL28813644 | 0.70 | MAOA (0.59) | PBRM1ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL2106757 | 0.70 | PBRM1 (0.67) | PBRM1ALDH1A1KDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12583856-B2 | Inhibitors of protein kinase A | BLUEPRINT MEDICINES CORPORATION (US) | 2026-03-24 | — | — | US | disclosed |
| US-20240132490-A1 | INHIBITORS OF PROTEIN KINASE A | BLUEPRINT MEDICINES CORPORATION (US) | 2024-04-25 | — | — | US | disclosed |
| WO-2022165402-A1 | INHIBITORS OF PROTEIN KINASE A | BLUEPRINT MEDICINES CORPORATION (US) | 2022-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12583856-B2 | Inhibitors of protein kinase A | CSNK1A1, CSNK1A1L, CSNK1G1 | PBRM1 1534/4885ALDH1A1 2595/4885KDM4E 1891/4885 |
| US-20240132490-A1 | INHIBITORS OF PROTEIN KINASE A | PRKCA, MAP3K6, MAP3K1 | PBRM1 1719/4885ALDH1A1 2528/4885KDM4E 2013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.