SCHEMBL272075

SCHEMBL272075

O=c1c(O)c(CN2CCC(N3CCCCC3)CC2)ccn1Cc1ccccc1

nearest known ligand 0.70

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
VEGFA P15692 12/20 0.70
EGLN1 Q9GZT9 12/20 0.70
RECQL P46063 2/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
ALDH1A1 P00352 1/20 0.50
TSHR P16473 1/20 0.50
HRH3 Q9Y5N1 1/20 0.46
MBTD1 Q05BQ5 2/20 0.45
L3MBTL3 Q96JM7 2/20 0.45
SMN1; SMN2 Q16637 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5267745 0.99 VEGFA (0.69) VEGFAEGLN1RECQLL3MBTL1ALDH1A1
SCHEMBL271963 0.88 EGLN1 (0.85) VEGFAEGLN1HRH3SMN1; SMN2
SCHEMBL277668 0.88 EGLN1 (0.85) VEGFAEGLN1HRH3SMN1; SMN2
SCHEMBL273696 0.88 EGLN1 (0.85) VEGFAEGLN1HRH3SMN1; SMN2
SCHEMBL273037 0.87 EGLN1 (0.87) VEGFAEGLN1ALDH1A1SMN1; SMN2
SCHEMBL12598832 0.86 VEGFA (0.73) VEGFAEGLN1ALDH1A1
SCHEMBL17340662 0.85 VEGFA (0.49) VEGFAEGLN1RECQLL3MBTL1ALDH1A1
SCHEMBL278202 0.83 VEGFA (1.00) VEGFAEGLN1ALDH1A1SMN1; SMN2
SCHEMBL278211 0.83 VEGFA (0.75) VEGFAEGLN1ALDH1A1
SCHEMBL277620 0.81 EGLN1 (0.71) VEGFAEGLN1ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2496082-B1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS INC (US) 2016-10-12 EP claimed
US-20150157617-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS LLC 2015-06-11 US claimed
US-8999971-B2 Methods for increasing the stabilization of hypoxia inducible factor-1 alpha AERPIO THERAPEUTICS INC. (US) 2015-04-07 US claimed
US-20140364419-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS LLC 2014-12-11 US claimed
US-20130158010-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS INC. (US) 2013-06-20 US claimed
US-20110111058-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS LLC 2011-05-12 US claimed
US-20070270407-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones THE PROCTER & GAMBLE COMPANY 2007-11-22 US claimed
CN-116018136-A Hypoxia-inducible factor prolyl hydroxylase inhibitors for the treatment of aging-related disorders 百爱及生物医药公司 2023-04-25 CN disclosed
US-20220185778-A1 PROLYL HYDROXYLASE INHIBITORS AERPIO THERAPEUTICS INC (US) 2022-06-16 US disclosed
US-20220185778-A1 PROLYL HYDROXYLASE INHIBITORS AERPIO THERAPEUTICS INC (US) 2022-06-16 US disclosed
US-20210353612-A1 HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE INHIBITORS FOR TREATING AGING-RELATED CONDITIONS BioAge Labs, Inc. 2021-11-18 US disclosed
EP-3698794-A1 COMPOSITIONS AND METHODS FOR TREATING COLITIS Aerpio Therapeutics, Inc. (US) 2020-08-26 EP disclosed
US-10562854-B2 Prolyl hydroxylase inhibitors AERPIO THERAPEUTICS, INC. (US) 2020-02-18 US disclosed
WO-2011057121-A1 COMPOSITIONS AND METHODS FOR TREATING COLITIS AKEBIA THERAPEUTICS INC. (US) 2011-05-12 WO disclosed
WO-2011057121-A1 COMPOSITIONS AND METHODS FOR TREATING COLITIS AKEBIA THERAPEUTICS INC. (US) 2011-05-12 WO disclosed
US-20070270407-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones THE PROCTER & GAMBLE COMPANY 2007-11-22 US disclosed
US-7247648-B2 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones THE PROCTER & GAMBLE COMPANY (US) 2007-07-24 US disclosed
US-20050234045-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones THE PROCTER & GAMBLE COMPANY (US) 2005-10-20 US disclosed
US-6930117-B2 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones THE PROCTER & GAMBLE COMPANY (US) 2005-08-16 US disclosed
US-20040097560-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones THE PROCTER & GAMBLE COMPANY 2004-05-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150157617-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA HIF1A, HIF1AN, EGLN3 VEGFA 20/4885EGLN1 8/4885RECQL 2334/4885
US-20210353612-A1 HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE INHIBITORS FOR TREATING AGING-RELATED CONDITIONS HIF1AN, HIF1A, P4HA1 VEGFA 384/4885EGLN1 11/4885RECQL 2461/4885
US-20040097560-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones IL17A, CYP51A1, CD4 VEGFA 3112/4885EGLN1 926/4885RECQL 767/4885
US-20070270407-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones IL17A, IFNG, CD4 VEGFA 2758/4885EGLN1 1060/4885RECQL 698/4885
US-20220185778-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, HIF1A, EGLN2 VEGFA 551/4885EGLN1 5/4885RECQL 3996/4885
US-20050234045-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones IL17A, IFNG, CD4 VEGFA 3064/4885EGLN1 1182/4885RECQL 705/4885
US-20110111058-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA HIF1A, HIF1AN, EGLN3 VEGFA 20/4885EGLN1 8/4885RECQL 2334/4885
US-20140364419-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA HIF1A, HIF1AN, EGLN3 VEGFA 20/4885EGLN1 8/4885RECQL 2334/4885
US-20130158010-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA HIF1A, HIF1AN, EGLN3 VEGFA 20/4885EGLN1 8/4885RECQL 2334/4885
US-10562854-B2 Prolyl hydroxylase inhibitors HIF1AN, HIF1A, EGLN2 VEGFA 551/4885EGLN1 5/4885RECQL 3996/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.