SCHEMBL27210453

SCHEMBL27210453

O=C(O)c1cc(C(=O)c2ccccc2)n2c1c(Br)cc1ccccc12

nearest known ligand 0.51

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ FNTA P49354 10/20 0.51
▸ FNTB P49356 10/20 0.51
▸ DAO P14920 1/20 0.41
▸ MAPT P10636 1/20 0.40
▸ MCL1 Q07820 1/20 0.40
▸ ALDH1A1 P00352 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ AKR1C3 P42330 2/20 0.39
▸ PLA2G10 O15496 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.38
▸ CCR2 P41597 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5959268 0.82 EGFR (0.40) FNTAFNTBDAOMAPTMCL1
SCHEMBL27156314 0.77 DAO (0.37) FNTAFNTBDAOMAPTMCL1
SCHEMBL27156298 0.77 FNTA (0.53) FNTAFNTBMAPTKDM4E
SCHEMBL27156309 0.75 FNTA (0.52) FNTAFNTBALDH1A1KDM4E
SCHEMBL27156308 0.75 NOD2 (0.48) FNTAFNTBALDH1A1KDM4E
SCHEMBL27156302 0.74 FNTA (0.44) FNTAFNTBALDH1A1KDM4E
SCHEMBL27156306 0.72 AKR1C3 (0.43) FNTAFNTBDAOMAPTMCL1
SCHEMBL27156307 0.70 NR4A1 (0.42) FNTAFNTBMAPTALDH1A1TSHR
SCHEMBL27156303 0.70 NPC1 (0.37) FNTAFNTBDAOMAPTALDH1A1
SCHEMBL5959188 0.69 PTPN1 (0.40) FNTAFNTBMAPTMCL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11974991-B1 Adenosine receptor activity of methyl/ethyl 3-(substituted benzoyl)-6,8-dimethylindolizine-2-substituted-1-carboxylates King Faisal University (SA) 2024-05-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11974991-B1 Adenosine receptor activity of methyl/ethyl 3-(substituted benzoyl)-6,8-dimethylindolizine-2-substituted-1-carboxylates ADORA2A, ADORA1, ADORA3 FNTA 1088/4885FNTB 1915/4885DAO 872/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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