Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Disulfiram. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH2 known ✓ | P05091 | 7/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 1.00 |
| ▸ | MGLL | Q99685 | 7/20 | 1.00 |
| ▸ | EHMT2 | Q96KQ7 | 4/20 | 1.00 |
| ▸ | EHMT1 | Q9H9B1 | 4/20 | 1.00 |
| ▸ | PHGDH | O43175 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | HTT | P42858 | 3/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | GSDMD | P57764 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 1.00 |
| ▸ | FBP1 | P09467 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | PKM | P14618 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 2/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 2/20 | 1.00 |
| ▸ | LOX | P28300 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Disulfiram SCHEMBL4654748 | 1.00 | ALDH1A1 (1.00) | ALDH1A1ALDH2MGLLEHMT2EHMT1 | |
| Disulfiram SCHEMBL5961375 | 0.97 | ALDH1A1 (0.94) | ALDH1A1ALDH2MGLLEHMT2EHMT1 | |
| Disulfiram SCHEMBL28074264 | 0.97 | ALDH1A1 (0.94) | ALDH1A1ALDH2MGLLEHMT2EHMT1 | |
| Disulfiram SCHEMBL31719635 | 0.97 | ALDH1A1 (0.94) | ALDH1A1ALDH2MGLLEHMT2EHMT1 | |
| Disulfiram SCHEMBL28246322 | 0.97 | ALDH1A1 (0.94) | ALDH1A1ALDH2MGLLEHMT2EHMT1 | |
| Disulfiram SCHEMBL5364281 | 0.97 | ALDH1A1 (0.94) | ALDH1A1ALDH2MGLLEHMT2EHMT1 | |
| Disulfiram SCHEMBL10886601 | 0.97 | ALDH1A1 (0.94) | ALDH1A1ALDH2MGLLEHMT2EHMT1 | |
| Disulfiram SCHEMBL11155542 | 0.97 | ALDH1A1 (0.94) | ALDH1A1ALDH2MGLLEHMT2EHMT1 | |
| Disulfiram SCHEMBL10542872 | 0.94 | ALDH1A1 (0.89) | ALDH1A1ALDH2MGLLEHMT2EHMT1 | |
| Disulfiram SCHEMBL4734237 | 0.94 | ALDH1A1 (0.89) | ALDH1A1ALDH2MGLLEHMT2EHMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 43256 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| EP-4228644-B1 | N-[4-[1-(1,4-DIOXASPIRO[4.5]DEC-8-YL)-4-(8-OXA-3-AZABICYCLO[3.2.1]OCT-3-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-YL]PHENYL]-N'-METHYLUREA FOR USE IN THE TREATMENT OF COVID19 | NANTCELL INC (US) | 2026-05-27 | — | — | EP | claimed |
| US-20260137794-A1 | LIGAND-DRUG CONJUGATE AND USE THEREOF | SYSTIMMUNE INC (US) | 2026-05-21 | — | — | US | claimed |
| WO-2026107208-A1 | COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS | THE METHODIST HOSPITAL (US) | 2026-05-21 | — | — | WO | claimed |
| US-20260137082-A1 | FUNGICIDAL COMPOSITIONS COMPRISING FLUDIOXONIL | SYNGENTA CROP PROTECTION AG (CH) | 2026-05-21 | — | — | US | claimed |
| CN-122037329-A | Double-network crosslinked carcass rubber composition of cracked carbon black-bio-based liquid rubber and preparation method thereof | 中策橡胶集团股份有限公司 | 2026-05-15 | — | — | CN | claimed |
| EP-4739293-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF AUTOIMMUNE DISORDERS | AZURA OPHTHALMICS LTD (IL) | 2026-05-13 | — | — | EP | claimed |
| EP-3986465-B1 | SITE-SPECIFIC, KINETICALLY INERT CONJUGATION OF LABELS AND/OR CARRIERS TO TARGET MOLECULES SUCH AS HIS-TAGGED PROTEINS VIA METAL COMPLEX REAGENTS | MAX PLANCK GESELLSCHAFT (DE) | 2026-05-13 | — | — | EP | claimed |
| EP-4739291-A2 | ADMINISTRATION OF KERATOLYTICS TO OCULAR AND PERIOCULAR SURFACES | AZURA OPHTHALMICS LTD (IL) | 2026-05-13 | — | — | EP | claimed |
| CN-119431911-B | Rubber capable of expanding rapidly when meeting water for petroleum casing pipe and preparation method and application thereof | 中国石油天然气集团有限公司 | 2026-05-12 | — | — | CN | claimed |
| US-4133755-A | DITHIOCARBAMATE SULFIDE COMPOUND, AMORPHOUS SILICA, AND ACTIVE CARBON | CHISSO CORPORATION (JP) | 1979-01-09 | — | — | US | claimed |
| US-4129609-A | Method for improving storage stability of epoxy ester thermosetting resins with thiuram compounds | NIPPON SHOKUBAI KAGAKU KOGYO CO., LTD. (JP) | 1978-12-12 | — | — | US | claimed |
| US-4124754-A | POLYMERIZATION OF CHLOROPRENE IN THE PRESENCE OF SULFUR | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1978-11-07 | — | — | US | claimed |
| US-4098858-A | DUSTLESS FREE FLOWING RUBBER ADDITIVES | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1978-07-04 | — | — | US | claimed |
| US-4060624-A | Controlling fungal crop diseases with mixtures of methyl 2-benzimidazolecarbamate and certain specific fungicides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-11-29 | — | — | US | claimed |
| US-4036804-A | POLYMERIC COMPOUND HAVING A CARBOXYL GROUP; VULCANIZING AGENT | NIPPON PAINT CO., LTD. (JA) | 1977-07-19 | — | — | US | claimed |
| US-4020033-A | Polythioether sealant compositions | HOOKER CHEMICALS & PLASTICS CORPORATION (US) | 1977-04-26 | — | — | US | claimed |
| US-3994840-A | DITHIOCARBAMATE | SEKISUI KASEIHIN KOGYO KABUSHIKI KAISHA (JA) | 1976-11-30 | — | — | US | claimed |
| US-3951190-A | Heat-resistant fuel cell | GOODYEAR AEROSPACE CORPORATION (US) | 1976-04-20 | — | — | US | claimed |
| US-3932346-A | ACRYLIC ESTERS, COATINGS, PRINTING INKS | CONTINENTAL CAN COMPANY, INC. (US) | 1976-01-13 | — | — | US | claimed |