Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Disulfiram. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH2 known ✓ | P05091 | 7/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.94 |
| ▸ | MGLL | Q99685 | 7/20 | 0.94 |
| ▸ | EHMT2 | Q96KQ7 | 4/20 | 0.94 |
| ▸ | EHMT1 | Q9H9B1 | 4/20 | 0.94 |
| ▸ | PHGDH | O43175 | 3/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.94 |
| ▸ | HTT | P42858 | 3/20 | 0.94 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.94 |
| ▸ | GSDMD | P57764 | 2/20 | 0.94 |
| ▸ | LMNA | P02545 | 2/20 | 0.94 |
| ▸ | TP53 | P04637 | 2/20 | 0.94 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.94 |
| ▸ | FBP1 | P09467 | 2/20 | 0.94 |
| ▸ | MAPT | P10636 | 2/20 | 0.94 |
| ▸ | PKM | P14618 | 2/20 | 0.94 |
| ▸ | HPGD | P15428 | 2/20 | 0.94 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.94 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.94 |
| ▸ | LOX | P28300 | 2/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Disulfiram SCHEMBL27213 | 0.97 | ALDH1A1 (1.00) | ALDH1A1ALDH2MGLLEHMT2EHMT1 | |
| Disulfiram SCHEMBL4654748 | 0.97 | ALDH1A1 (1.00) | ALDH1A1ALDH2MGLLEHMT2EHMT1 | |
| Disulfiram SCHEMBL5364281 | 0.94 | ALDH1A1 (0.94) | ALDH1A1ALDH2MGLLEHMT2EHMT1 | |
| Disulfiram SCHEMBL28867973 | 0.94 | ALDH1A1 (0.94) | ALDH1A1ALDH2MGLLEHMT2EHMT1 | |
| Disulfiram SCHEMBL28246322 | 0.94 | ALDH1A1 (0.94) | ALDH1A1ALDH2MGLLEHMT2EHMT1 | |
| Disulfiram SCHEMBL28998625 | 0.94 | ALDH1A1 (0.94) | ALDH1A1ALDH2MGLLEHMT2EHMT1 | |
| Disulfiram SCHEMBL10886601 | 0.94 | ALDH1A1 (0.94) | ALDH1A1ALDH2MGLLEHMT2EHMT1 | |
| Disulfiram SCHEMBL11155542 | 0.94 | ALDH1A1 (0.94) | ALDH1A1ALDH2MGLLEHMT2EHMT1 | |
| Disulfiram SCHEMBL31719635 | 0.94 | ALDH1A1 (0.94) | ALDH1A1ALDH2MGLLEHMT2EHMT1 | |
| Disulfiram SCHEMBL29067672 | 0.94 | ALDH1A1 (0.94) | ALDH1A1ALDH2MGLLEHMT2EHMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622599-A2 | METHOD OF INHIBITING ATF/CREB AND CANCER CELL GROWTH AND PHARMACEUTICAL COMPOSITIONS FOR SAME | CHARLOTTE-MECKLENBURG HOSPITAL doing business as Carolinas Medical Center (US) | 2006-02-08 | — | — | EP | disclosed |
| EP-1214063-B1 | TREATING CANCER USING TETRAETHYL THIURAM DISULFIDE | CHARLOTTE MECKLENBURG HOSPITAL (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2005009338-A2 | METHOD OF INHIBITING ATF/CREB AND CANCER CELL GROWTH AND PHARMACEUTICAL COMPOSITIONS FOR SAME | CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY D/B/A/ CAROLINAS MEDICAL CENTER (US) | 2005-02-03 | — | — | WO | disclosed |
| US-6589987-B2 | Dithiocarbamate, particularly tetraethylthiuram disulfide strongly inhibits the growth of cancer cells of a variety of cell types. Such inhibitory effect is enhanced by heavy metal ions such as copper ions, cytokines and ceruloplasmin and | CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY | 2003-07-08 | — | — | US | disclosed |
| US-20030065026-A1 | METHOD OF TREATING CANCER USING TETRAETHYL THIURAM DISULFIDE | UNIVERSITY OF UTAH RESEARCH FOUNDATION | 2003-04-03 | — | — | US | disclosed |
| EP-1214063-A1 | METHOD OF TREATING CANCER USING TETRAETHYL THIURAM DISULFIDE | Charlotte-Mecklenburg Hospital Authority doing business as Carolinas Medical Center (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017522-A1 | METHOD OF TREATING CANCER USING TETRAETHYL THIURAM DISULFIDE | CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY DOING BUSINESS AS CAROLINAS MEDICAL CENTER (US) | 2001-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030065026-A1 | METHOD OF TREATING CANCER USING TETRAETHYL THIURAM DISULFIDE | TST, TTPA, THPO | ALDH2 289/4885ALDH1A1 1100/4885MGLL 4116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.