SCHEMBL27218855

SCHEMBL27218855

c1cc2c(cc1-c1noc(CSc3nnc(C4CC4)o3)n1)OCO2

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ USP2 O75604 2/20 0.48
▸ KDM4E B2RXH2 1/20 0.48
▸ TSHR P16473 1/20 0.48
▸ L3MBTL1 Q9Y468 1/20 0.48
▸ LMNA P02545 1/20 0.48
▸ CHRM2 P08172 1/20 0.47
▸ CHRM5 P08912 1/20 0.47
▸ CHRM1 P11229 1/20 0.47
▸ RAB9A P51151 6/20 0.46
▸ NPC1 O15118 4/20 0.46
▸ GSK3A P49840 8/20 0.45
▸ GSK3B P49841 8/20 0.45
▸ MAPT P10636 2/20 0.45
▸ GAA P10253 1/20 0.45
▸ CSNK1E P49674 3/20 0.43
▸ AURKA O14965 2/20 0.43
▸ SMN1; SMN2 Q16637 2/20 0.42
▸ MEN1 O00255 1/20 0.42
▸ PKM P14618 1/20 0.42
▸ KMT2A Q03164 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27218757 0.95 USP2 (0.46) USP2KDM4ETSHRL3MBTL1LMNA
SCHEMBL27218818 0.84 MAPT (0.53) USP2KDM4ETSHRL3MBTL1CHRM2
SCHEMBL17695682 0.82 GSK3A (0.61) TSHRL3MBTL1LMNARAB9ANPC1
SCHEMBL27218805 0.81 TSHR (0.48) USP2KDM4ETSHRL3MBTL1CHRM2
SCHEMBL27218731 0.80 GSK3A (0.69) USP2KDM4ETSHRL3MBTL1CHRM2
SCHEMBL27218916 0.78 MAPT (0.50) USP2KDM4ETSHRL3MBTL1LMNA
SCHEMBL31494419 0.76 NPC1 (0.46) USP2KDM4ETSHRL3MBTL1LMNA
SCHEMBL27218931 0.76 GAA (0.49) KDM4ETSHRL3MBTL1LMNACHRM2
SCHEMBL31494427 0.76 TSHR (0.70) USP2KDM4ETSHRL3MBTL1LMNA
SCHEMBL27218710 0.76 LMNA (0.46) TSHRL3MBTL1LMNACHRM2CHRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4232448-B1 AGONISTS OF FREE FATTY ACID RECEPTOR 1 AND THEIR USE IN DISEASES ASSOCIATED WITH SAID RECEPTOR Halo Therapeutics Ltd (GB) 2025-05-07 — — EP disclosed
EP-3956323-B1 OXAZOLE AND OXADIAZOLE DERIVATIVES USEFUL AS AGONISTS OF FREE FATTY ACID RECEPTOR 1 Halo Therapeutics Ltd (GB) 2025-03-05 — — EP disclosed
US-20240158382-A1 Agonists Of Free Fatty Acid Receptor 1 And Their Use In Diseases Associated With Said Receptor Halo Therapeutics Ltd (GB) 2024-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240158382-A1 Agonists Of Free Fatty Acid Receptor 1 And Their Use In Diseases Associated With Said Receptor FFAR1, FFAR2, FFAR3 USP2 2633/4885KDM4E 3870/4885TSHR 151/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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