SCHEMBL27220398

SCHEMBL27220398

COc1ccc(/C=C/C(=O)Oc2ccc(/C=N/O)cc2OC)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 4/20 0.57
▸ SMN1; SMN2 Q16637 3/20 0.57
▸ KDM4E B2RXH2 2/20 0.57
▸ ALDH1A1 P00352 1/20 0.57
▸ MAPT P10636 3/20 0.56
▸ MEN1 O00255 1/20 0.56
▸ NPC1 O15118 2/20 0.56
▸ RAB9A P51151 2/20 0.56
▸ TNFRSF1A P19438 2/20 0.54
▸ ABCG2 Q9UNQ0 2/20 0.54
▸ TUBB4A P04350 1/20 0.51
▸ TUBB P07437 1/20 0.51
▸ TUBA3C P0DPH7 1/20 0.51
▸ TUBA1B P68363 1/20 0.51
▸ TUBA4A P68366 1/20 0.51
▸ TUBB4B P68371 1/20 0.51
▸ TUBB3 Q13509 1/20 0.51
▸ TUBB2A Q13885 1/20 0.51
▸ TUBB8 Q3ZCM7 1/20 0.51
▸ TUBA3E Q6PEY2 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27220275 1.00 KMT2A (0.57) KMT2ASMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL27220135 0.90 SMN1; SMN2 (0.54) KMT2ASMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL27220303 0.90 SMN1; SMN2 (0.54) KMT2ASMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL27220418 0.90 SMN1; SMN2 (0.54) KMT2ASMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL27220410 0.89 KMT2A (0.52) KMT2ASMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL27220281 0.89 SMN1; SMN2 (0.58) KMT2ASMN1; SMN2KDM4EALDH1A1MEN1
SCHEMBL27220386 0.89 SMN1; SMN2 (0.58) KMT2ASMN1; SMN2KDM4EALDH1A1MEN1
SCHEMBL27220159 0.89 KMT2A (0.52) KMT2ASMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL27220324 0.88 NQO2 (0.56) KMT2ASMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL27231520 0.88 NQO2 (0.56) KMT2ASMN1; SMN2KDM4EALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220234987-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2022-07-28 — — US claimed
US-12637409-B2 Styryl carboxylate derivatives Renovel Innovations, Inc. (US) 2026-05-26 — — US disclosed
US-20240317670-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2024-09-26 — — US disclosed
US-20240300883-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2024-09-12 — — US disclosed
US-11987551-B2 Styryl carboxylate derivatives Renovel Innovations, Inc. 2024-05-21 — — US disclosed
US-20220234987-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2022-07-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220234987-A1 STYRYL CARBOXYLATE DERIVATIVES ACACB, ACACA, FABP7 KMT2A 1056/4885SMN1; SMN2 2759/4885KDM4E 846/4885
US-20240300883-A1 STYRYL CARBOXYLATE DERIVATIVES SCD, ACACB, ACACA KMT2A 780/4885SMN1; SMN2 3684/4885KDM4E 492/4885
US-20240317670-A1 STYRYL CARBOXYLATE DERIVATIVES ACACB, ACACA, GPR119 KMT2A 995/4885SMN1; SMN2 2950/4885KDM4E 803/4885
US-12637409-B2 Styryl carboxylate derivatives GPR119, ACACB, ACACA KMT2A 778/4885SMN1; SMN2 2149/4885KDM4E 580/4885
US-11987551-B2 Styryl carboxylate derivatives ACACB, ACACA, FABP7 KMT2A 1056/4885SMN1; SMN2 2759/4885KDM4E 846/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback