Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2723700 | 0.82 | KDM4E (0.59) | KMT2AKDM4EGLATDP1NPC1 | |
| SCHEMBL18191353 | 0.73 | KMT2A (1.00) | KMT2AKDM4ETDP1TSHRNPC1 | |
| SCHEMBL2722136 | 0.73 | KDM4E (0.55) | KMT2AKDM4EGLATDP1NPC1 | |
| SCHEMBL30507791 | 0.69 | KDM4E (0.50) | KMT2AKDM4EGLATDP1NPC1 | |
| SCHEMBL6922909 | 0.69 | MAPK1 (0.51) | KMT2AKDM4EGLATDP1NPC1 | |
| SCHEMBL17950444 | 0.69 | KDM4E (0.50) | KMT2AKDM4EGLATDP1NPC1 | |
| SCHEMBL3727866 | 0.68 | KMT2A (0.67) | KMT2AKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL17449515 | 0.68 | KMT2A (0.46) | KMT2AKDM4ETDP1TSHRRAB9A | |
| SCHEMBL2993540 | 0.68 | TSHR (0.62) | KMT2AKDM4ETSHRNPC1ALDH1A1 | |
| SCHEMBL22547358 | 0.66 | KMT2A (0.65) | KMT2AKDM4ERAB9AHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054332-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |