Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2119122 | 0.84 | HDAC6 (0.49) | — | |
| SCHEMBL2118762 | 0.84 | ALDH1A1 (0.55) | HSD17B10TDP1HTTMEN1KMT2A | |
| SCHEMBL9919081 | 0.80 | MEN1 (0.40) | MAPK1HSD17B10TDP1MEN1KMT2A | |
| SCHEMBL554569 | 0.80 | HSD17B10 (0.64) | HSD17B10TDP1HTTMEN1KMT2A | |
| SCHEMBL19359658 | 0.80 | ESR1 (0.54) | HSD17B10AKR1B1KMT2AKDM4EMAPT | |
| SCHEMBL5986479 | 0.79 | CYP3A4 (0.48) | TDP1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL15840322 | 0.76 | L3MBTL1 (0.49) | MEN1KMT2ARAB9ANPC1L3MBTL1 | |
| SCHEMBL1161500 | 0.76 | CASP3 (0.43) | MAPK1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL18247596 | 0.76 | TDP1 (0.53) | HSD17B10TDP1HTTMEN1KMT2A | |
| SCHEMBL8845824 | 0.76 | KMT2A (0.57) | MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075699-A2 | COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2011-06-23 | — | — | WO | disclosed |